4esx

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:47, 3 April 2024) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:4esx.jpg|left|200px]]
 
-
{{STRUCTURE_4esx| PDB=4esx | SCENE= }}
+
==Crystal structure of C. albicans Thi5 complexed with PLP==
-
 
+
<StructureSection load='4esx' size='340' side='right'caption='[[4esx]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-
===Crystal structure of C. albicans Thi5 complexed with PLP===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[4esx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans_WO-1 Candida albicans WO-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ESX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ESX FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_22568620}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4esx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4esx OCA], [https://pdbe.org/4esx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4esx RCSB], [https://www.ebi.ac.uk/pdbsum/4esx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4esx ProSAT]</span></td></tr>
-
[[4esx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ESX OCA].
+
</table>
-
[[Category: Candida albicans]]
+
== Function ==
-
[[Category: Begley, T P.]]
+
[https://www.uniprot.org/uniprot/THI5_CANAW THI5_CANAW] Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme.<ref>PMID:22568620</ref>
-
[[Category: Ealick, S E.]]
+
== References ==
-
[[Category: Fenwick, M K.]]
+
<references/>
-
[[Category: Hazra, A.]]
+
__TOC__
-
[[Category: Huang, S.]]
+
</StructureSection>
-
[[Category: Kinsland, C.]]
+
[[Category: Candida albicans WO-1]]
-
[[Category: Lai, R.]]
+
[[Category: Large Structures]]
-
[[Category: Philmus, B.]]
+
[[Category: Begley TP]]
-
[[Category: Rajashankar, K]]
+
[[Category: Ealick SE]]
-
[[Category: Sanders, J.]]
+
[[Category: Fenwick MK]]
-
[[Category: Zhang, Y.]]
+
[[Category: Hazra A]]
-
[[Category: Thiamin pyrimidine biosynthesis]]
+
[[Category: Huang S]]
-
[[Category: Transferase]]
+
[[Category: Kinsland C]]
 +
[[Category: Lai R]]
 +
[[Category: Philmus B]]
 +
[[Category: Rajashankar K]]
 +
[[Category: Sanders J]]
 +
[[Category: Zhang Y]]

Current revision

Crystal structure of C. albicans Thi5 complexed with PLP

PDB ID 4esx

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4esx"
Personal tools