4fhi

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[[Image:4fhi.jpg|left|200px]]
 
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{{STRUCTURE_4fhi| PDB=4fhi | SCENE= }}
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==Development of synthetically accessible non-secosteroidal hybrid molecules combining vitamin D receptor agonism and histone deacetylase inhibition==
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<StructureSection load='4fhi' size='340' side='right'caption='[[4fhi]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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===Development of synthetically accessible non-secosteroidal hybrid molecules combining vitamin D receptor agonism and histone deacetylase inhibition===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4fhi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FHI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FHI FirstGlance]. <br>
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{{ABSTRACT_PUBMED_22921063}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0S4:N-HYDROXY-2-{4-[3-(4-{[(2R)-2-HYDROXY-3,3-DIMETHYLBUTYL]OXY}-3-METHYLPHENYL)PENTAN-3-YL]-2-METHYLPHENOXY}ACETAMIDE'>0S4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fhi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fhi OCA], [https://pdbe.org/4fhi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fhi RCSB], [https://www.ebi.ac.uk/pdbsum/4fhi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fhi ProSAT]</span></td></tr>
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[[4fhi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FHI OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/VDRA_DANRE VDRA_DANRE] Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Plays a central role in calcium homeostasis.<ref>PMID:17218092</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Danio rerio]]
[[Category: Danio rerio]]
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[[Category: Fischer, J.]]
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[[Category: Homo sapiens]]
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[[Category: Gleason, J L.]]
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[[Category: Large Structures]]
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[[Category: Kaldre, D.]]
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[[Category: Fischer J]]
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[[Category: Moras, D.]]
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[[Category: Gleason JL]]
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[[Category: Rochel, N.]]
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[[Category: Kaldre D]]
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[[Category: Wang, T T.]]
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[[Category: Moras D]]
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[[Category: White, J H.]]
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[[Category: Rochel N]]
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[[Category: Alpha helical sandwich]]
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[[Category: Wang TT]]
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[[Category: Dna coregulator]]
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[[Category: White JH]]
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[[Category: Ligand binding domain alpha helical sandwich]]
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[[Category: Nucleus]]
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[[Category: Phosphorylation]]
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[[Category: Transcription factor]]
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[[Category: Transcription-protein binding-inhibitor complex]]
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Development of synthetically accessible non-secosteroidal hybrid molecules combining vitamin D receptor agonism and histone deacetylase inhibition

PDB ID 4fhi

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