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3sud

From Proteopedia

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[[Image:3sud.jpg|left|200px]]
 
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{{STRUCTURE_3sud| PDB=3sud | SCENE= }}
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==Crystal structure of NS3/4A protease in complex with MK-5172==
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<StructureSection load='3sud' size='340' side='right'caption='[[3sud]], [[Resolution|resolution]] 1.96&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3sud]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepatitis_C_virus_genotype_1a Hepatitis C virus genotype 1a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SUD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SUD FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.96&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SUE:(1AR,5S,8S,10R,22AR)-5-TERT-BUTYL-N-{(1R,2S)-1-[(CYCLOPROPYLSULFONYL)CARBAMOYL]-2-ETHENYLCYCLOPROPYL}-14-METHOXY-3,6-DIOXO-1,1A,3,4,5,6,9,10,18,19,20,21,22,22A-TETRADECAHYDRO-8H-7,10-METHANOCYCLOPROPA[18,19][1,10,3,6]DIOXADIAZACYCLONONADECINO[11,12-B]QUINOXALINE-8-CARBOXAMIDE'>SUE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sud OCA], [https://pdbe.org/3sud PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sud RCSB], [https://www.ebi.ac.uk/pdbsum/3sud PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sud ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/A8DG50_9HEPC A8DG50_9HEPC]
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===Crystal structure of NS3/4A protease in complex with MK-5172===
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==See Also==
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*[[Virus protease 3D structures|Virus protease 3D structures]]
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{{ABSTRACT_PUBMED_22910833}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Hepatitis C virus genotype 1a]]
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[[3sud]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SUD OCA].
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[[Category: Large Structures]]
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[[Category: Hepatitis c virus]]
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[[Category: Romano KP]]
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[[Category: Romano, K P.]]
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[[Category: Schiffer CA]]
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[[Category: Schiffer, C A.]]
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[[Category: Drug design]]
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[[Category: Drug resistance]]
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[[Category: Hcv]]
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[[Category: Hydrolase-inhibitor complex]]
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[[Category: Protease inhibitor]]
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[[Category: Serine protease]]
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[[Category: Viral protein]]
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Current revision

Crystal structure of NS3/4A protease in complex with MK-5172

PDB ID 3sud

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