4fhh

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[[Image:4fhh.jpg|left|200px]]
 
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{{STRUCTURE_4fhh| PDB=4fhh | SCENE= }}
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==Development of synthetically accessible non-secosteroidal hybrid molecules combining vitamin D receptor agonism and histone deacetylase inhibition==
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<StructureSection load='4fhh' size='340' side='right'caption='[[4fhh]], [[Resolution|resolution]] 2.33&Aring;' scene=''>
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===Development of synthetically accessible non-secosteroidal hybrid molecules combining vitamin D receptor agonism and histone deacetylase inhibition===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4fhh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FHH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FHH FirstGlance]. <br>
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{{ABSTRACT_PUBMED_22921063}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.33&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0U3:N-HYDROXY-2-{4-[3-(4-{[(2S)-2-HYDROXY-3,3-DIMETHYLBUTYL]OXY}-3-METHYLPHENYL)PENTAN-3-YL]-2-METHYLPHENOXY}ACETAMIDE'>0U3</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fhh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fhh OCA], [https://pdbe.org/4fhh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fhh RCSB], [https://www.ebi.ac.uk/pdbsum/4fhh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fhh ProSAT]</span></td></tr>
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[[4fhh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FHH OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/VDRA_DANRE VDRA_DANRE] Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Plays a central role in calcium homeostasis.<ref>PMID:17218092</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Danio rerio]]
[[Category: Danio rerio]]
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[[Category: Fischer, J.]]
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[[Category: Homo sapiens]]
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[[Category: Gleason, J L.]]
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[[Category: Large Structures]]
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[[Category: Kaldre, D.]]
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[[Category: Fischer J]]
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[[Category: Moras, D.]]
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[[Category: Gleason JL]]
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[[Category: Rochel, N.]]
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[[Category: Kaldre D]]
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[[Category: Wang, T T.]]
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[[Category: Moras D]]
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[[Category: White, J H.]]
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[[Category: Rochel N]]
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[[Category: Adn coregulator]]
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[[Category: Wang TT]]
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[[Category: Alpha helical sandwich]]
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[[Category: White JH]]
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[[Category: Apha helical sandwich]]
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[[Category: Ligand binding domain]]
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[[Category: Nucleus]]
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[[Category: Phosphorylation and hdac inhibitor]]
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[[Category: Transcription factor]]
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[[Category: Transcription-protein binding-inhibitor complex]]
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Current revision

Development of synthetically accessible non-secosteroidal hybrid molecules combining vitamin D receptor agonism and histone deacetylase inhibition

PDB ID 4fhh

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