4gw9
From Proteopedia
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| - | [[Image:4gw9.jpg|left|200px]] | ||
| - | + | ==Structure of a bacteriophytochrome and light-stimulated protomer swapping with a gene repressor== | |
| + | <StructureSection load='4gw9' size='340' side='right'caption='[[4gw9]], [[Resolution|resolution]] 2.90Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4gw9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodopseudomonas_palustris_CGA009 Rhodopseudomonas palustris CGA009]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4eho 4eho]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GW9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GW9 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BLA:BILIVERDINE+IX+ALPHA'>BLA</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gw9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gw9 OCA], [https://pdbe.org/4gw9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gw9 RCSB], [https://www.ebi.ac.uk/pdbsum/4gw9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gw9 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/B3Q7C0_RHOPT B3Q7C0_RHOPT] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Phytochromes are photoreceptors in phototropic organisms that respond to light conditions by changing interactions between a response regulator and DNA. Bacterial phytochromes (BphPs) comprise an input photosensory core domain (PCD) and an output transducing domain (OTD). We report the structure of a BphP containing both PCD and the majority of its OTD, and demonstrate interaction with its cognate repressor. The OTD of RpBphP1, from Rhodopseudomonas palustris, is composed of a PAS/PAC domain and, to our knowledge, a hitherto unrecognized two-helix output sensor (HOS) domain. Unlike canonical BphPs, it does not transmit phosphorelay signals but forms a complex with the transcriptional repressor RpPpsR2 on photoconversion with far-red light. We show that HOS is essential for complex formation and that the anti-parallel dimer geometry is crucial in achieving HOS domain activation and protomer swapping under the control of light. These results provide insights into the steps taken by a two-component signaling system. | ||
| - | + | Structure of a Bacteriophytochrome and Light-Stimulated Protomer Swapping with a Gene Repressor.,Bellini D, Papiz MZ Structure. 2012 Jul 10. PMID:22795083<ref>PMID:22795083</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 4gw9" style="background-color:#fffaf0;"></div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | == | + | __TOC__ |
| - | < | + | </StructureSection> |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Rhodopseudomonas palustris]] | + | [[Category: Rhodopseudomonas palustris CGA009]] |
| - | [[Category: Bellini | + | [[Category: Bellini D]] |
| - | [[Category: Papiz | + | [[Category: Papiz MZ]] |
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Current revision
Structure of a bacteriophytochrome and light-stimulated protomer swapping with a gene repressor
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