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4ac8

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[[Image:4ac8.jpg|left|200px]]
 
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{{STRUCTURE_4ac8| PDB=4ac8 | SCENE= }}
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==R2-like ligand binding Mn-Fe oxidase from M. tuberculosis with an organized C-terminal helix==
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<StructureSection load='4ac8' size='340' side='right'caption='[[4ac8]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4ac8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AC8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AC8 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ac8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ac8 OCA], [https://pdbe.org/4ac8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ac8 RCSB], [https://www.ebi.ac.uk/pdbsum/4ac8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ac8 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RIR2H_MYCTU RIR2H_MYCTU] Probable oxidase that might be involved in lipid metabolism.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Mycobacterium tuberculosis R2-like ligand-binding oxidase (MtR2lox) belongs to a recently discovered group of proteins that are homologous to the ribonucleotide reductase R2 proteins. MtR2lox carries a heterodinuclear Mn/Fe cofactor and, unlike R2 proteins, a large ligand-binding cavity. A unique tyrosine-valine cross link is also found in the vicinity of the active site. To date, all known structures of R2 and R2lox proteins show a disordered C-terminal segment. Here, we present two new crystal forms of MtR2lox, revealing an ordered helical C-terminal. The ability of alternating between an ordered and disordered state agrees well with bioinformatic analysis of the protein sequence. Interestingly, ordering of the C-terminal helix shields a large positively charged patch on the protein surface, potentially used for interaction with other cellular components. We hypothesize that the dynamic C-terminal segment may be involved in control of protein function in vivo.
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===R2-like ligand binding Mn-Fe oxidase from M. tuberculosis with an organized C-terminal helix===
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A Dynamic C-Terminal Segment in the Mycobacterium tuberculosis Mn/Fe R2lox Protein Can Adopt a Helical Structure with Possible Functional Consequences.,Andersson CS, Berthold CL, Hogbom M Chem Biodivers. 2012 Sep;9(9):1981-8. doi: 10.1002/cbdv.201100428. PMID:22976985<ref>PMID:22976985</ref>
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{{ABSTRACT_PUBMED_22976985}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4ac8" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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[[4ac8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AC8 OCA].
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*[[Ribonucleotide reductase 3D structures|Ribonucleotide reductase 3D structures]]
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[[Category: Mycobacterium tuberculosis]]
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== References ==
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[[Category: Ribonucleoside-diphosphate reductase]]
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<references/>
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[[Category: Andersson, C S.]]
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__TOC__
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[[Category: Berthold, C L.]]
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</StructureSection>
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[[Category: Hogbom, M.]]
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[[Category: Large Structures]]
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[[Category: Dimetal cofactor]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Metalloprotein]]
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[[Category: Andersson CS]]
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[[Category: Monooxygenase]]
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[[Category: Berthold CL]]
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[[Category: Oxidoreductase]]
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[[Category: Hogbom M]]

Current revision

R2-like ligand binding Mn-Fe oxidase from M. tuberculosis with an organized C-terminal helix

PDB ID 4ac8

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