3v5w

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[[Image:3v5w.jpg|left|200px]]
 
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{{STRUCTURE_3v5w| PDB=3v5w | SCENE= }}
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==Human G Protein-Coupled Receptor Kinase 2 in Complex with Soluble Gbetagamma Subunits and Paroxetine==
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<StructureSection load='3v5w' size='340' side='right'caption='[[3v5w]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3v5w]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V5W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V5W FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.07&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8PR:PAROXETINE'>8PR</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v5w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v5w OCA], [https://pdbe.org/3v5w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v5w RCSB], [https://www.ebi.ac.uk/pdbsum/3v5w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v5w ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ARBK1_HUMAN ARBK1_HUMAN] Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.<ref>PMID:19306925</ref>
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===Human G Protein-Coupled Receptor Kinase 2 in Complex with Soluble Gbetagamma Subunits and Paroxetine===
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==See Also==
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*[[Beta adrenergic receptor kinase 3D structures|Beta adrenergic receptor kinase 3D structures]]
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{{ABSTRACT_PUBMED_22882301}}
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*[[Regulator of G-protein signaling 3D structures|Regulator of G-protein signaling 3D structures]]
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*[[Transducin 3D structures|Transducin 3D structures]]
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==About this Structure==
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== References ==
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[[3v5w]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V5W OCA].
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<references/>
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__TOC__
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</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Tesmer, J J.G.]]
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[[Category: Large Structures]]
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[[Category: Thal, D M.]]
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[[Category: Tesmer JJG]]
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[[Category: Beta propeller]]
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[[Category: Thal DM]]
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[[Category: Inhibitor complex]]
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[[Category: Kinase]]
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[[Category: Peripheral membrane protein]]
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[[Category: Pleckstrin homology domain]]
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[[Category: Protein kinase]]
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[[Category: Rgs homology domain]]
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[[Category: Signal transduction]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

Human G Protein-Coupled Receptor Kinase 2 in Complex with Soluble Gbetagamma Subunits and Paroxetine

PDB ID 3v5w

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