4f6n
From Proteopedia
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| - | [[Image:4f6n.png|left|200px]] | ||
| - | + | ==Crystal structure of Kaiso zinc finger DNA binding protein in complex with methylated CpG site DNA== | |
| - | + | <StructureSection load='4f6n' size='340' side='right'caption='[[4f6n]], [[Resolution|resolution]] 2.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4f6n]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F6N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4F6N FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4f6n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f6n OCA], [https://pdbe.org/4f6n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4f6n RCSB], [https://www.ebi.ac.uk/pdbsum/4f6n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4f6n ProSAT]</span></td></tr> |
| - | [[4f6n]] is a 3 chain structure with sequence from [ | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/KAISO_HUMAN KAISO_HUMAN] Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3'. Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2.<ref>PMID:11445535</ref> <ref>PMID:14527417</ref> <ref>PMID:15548582</ref> <ref>PMID:15817151</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Buck-Koehntop | + | [[Category: Large Structures]] |
| - | [[Category: Dyson | + | [[Category: Buck-Koehntop BA]] |
| - | [[Category: Ekiert | + | [[Category: Dyson HJ]] |
| - | [[Category: Martinez-Yamout | + | [[Category: Ekiert DC]] |
| - | [[Category: Stanfield | + | [[Category: Martinez-Yamout MA]] |
| - | [[Category: Wilson | + | [[Category: Stanfield RL]] |
| - | [[Category: Wright | + | [[Category: Wilson IA]] |
| - | + | [[Category: Wright PE]] | |
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Current revision
Crystal structure of Kaiso zinc finger DNA binding protein in complex with methylated CpG site DNA
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