4gyq

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[[Image:4gyq.jpg|left|200px]]
 
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{{STRUCTURE_4gyq| PDB=4gyq | SCENE= }}
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==Crystal Structure of New Delhi Metallo-beta-Lactamase-1 D223A mutant from Klebsiella pneumoniae==
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<StructureSection load='4gyq' size='340' side='right'caption='[[4gyq]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4gyq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GYQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GYQ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.351&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gyq OCA], [https://pdbe.org/4gyq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gyq RCSB], [https://www.ebi.ac.uk/pdbsum/4gyq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gyq ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BLAN1_KLEPN BLAN1_KLEPN] Confers resistance to many beta-lactam antibiotics, including some carbapenems. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin.
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===Crystal Structure of New Delhi Metallo-beta-Lactamase-1 D223A mutant from Klebsiella pneumoniae===
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==See Also==
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*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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[[4gyq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GYQ OCA].
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[[Category: Beta-lactamase]]
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[[Category: Klebsiella pneumoniae]]
[[Category: Klebsiella pneumoniae]]
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[[Category: Babnigg, J.]]
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[[Category: Large Structures]]
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[[Category: Binkowski, T A.]]
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[[Category: Babnigg J]]
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[[Category: Jedrzejczak, R.]]
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[[Category: Binkowski TA]]
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[[Category: Joachimiak, A.]]
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[[Category: Jedrzejczak R]]
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[[Category: Kim, Y.]]
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[[Category: Joachimiak A]]
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[[Category: MCSG, Midwest Center for Structural Genomics.]]
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[[Category: Kim Y]]
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[[Category: MTBI, Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors.]]
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[[Category: MCSG]]
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[[Category: Mcsg]]
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[[Category: Mire J]]
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[[Category: Mire, J.]]
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[[Category: Sacchettini J]]
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[[Category: Sacchettini, J.]]
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[[Category: Tesar C]]
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[[Category: Tesar, C.]]
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[[Category: Alpha-beta-beta-alpha fold]]
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[[Category: Hydrolase]]
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[[Category: Mcsg]]
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[[Category: Midwest center for structural genomic]]
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[[Category: Mtbi]]
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[[Category: Psi-biology]]
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[[Category: Structural genomic]]
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[[Category: Structures of mtb proteins conferring susceptibility to known mtb inhibitor]]
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Current revision

Crystal Structure of New Delhi Metallo-beta-Lactamase-1 D223A mutant from Klebsiella pneumoniae

PDB ID 4gyq

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