4h7x
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4h7x is ON HOLD Authors: Bolanos-Garcia, V.M., Chirgadze, D.Y., Blundell, T.L. Description: Crystal structure of the tetratricopeptide repeat (TPR)...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the tetratricopeptide repeat (TPR) motif of human dual specificity protein kinase Mps1== | |
| + | <StructureSection load='4h7x' size='340' side='right'caption='[[4h7x]], [[Resolution|resolution]] 2.60Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4h7x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H7X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4H7X FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PB:LEAD+(II)+ION'>PB</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4h7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h7x OCA], [https://pdbe.org/4h7x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4h7x RCSB], [https://www.ebi.ac.uk/pdbsum/4h7x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4h7x ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Dual specificity protein kinase 3D structures|Dual specificity protein kinase 3D structures]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Blundell TL]] | ||
| + | [[Category: Bolanos-Garcia VM]] | ||
| + | [[Category: Chirgadze DY]] | ||
Current revision
Crystal structure of the tetratricopeptide repeat (TPR) motif of human dual specificity protein kinase Mps1
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