3zx7

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[[Image:3zx7.png|left|200px]]
 
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{{STRUCTURE_3zx7| PDB=3zx7 | SCENE= }}
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==Complex of lysenin with phosphocholine==
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<StructureSection load='3zx7' size='340' side='right'caption='[[3zx7]], [[Resolution|resolution]] 2.84&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3zx7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Eisenia_fetida Eisenia fetida]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZX7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZX7 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.84&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PC:PHOSPHOCHOLINE'>PC</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zx7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zx7 OCA], [https://pdbe.org/3zx7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zx7 RCSB], [https://www.ebi.ac.uk/pdbsum/3zx7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zx7 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TXL_EISFE TXL_EISFE] Pore-forming toxin that specifically binds sphingomyelin in the plasma membrane of various cells. Has hemolytic activity. Is also cytotoxic to spermatozoa of some species of invertebrates and many species of vertebrates and to amphibian larvae, guinea pig polymorphonuclear leukocytes, chicken fibroblasts, normal spleen cells and various tumor cells. Is lethal for various species of reptiles, amphibian, birds and mammals. Induces smooth muscle contraction. It binds sphingomyelin and induces hemolysis in the same manner as lysenin-related protein 2, and is 10 times more effective than lysenin-related protein 1.<ref>PMID:10684578</ref> <ref>PMID:12676961</ref> <ref>PMID:15274631</ref> <ref>PMID:16971770</ref> <ref>PMID:9210594</ref> <ref>PMID:9478988</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Pore-forming proteins insert from solution into membranes to create lesions, undergoing a structural rearrangement often accompanied by oligomerization. Lysenin, a pore-forming toxin from the earthworm Eisenia fetida, specifically interacts with sphingomyelin (SM) and may confer innate immunity against parasites by attacking their membranes to form pores. SM has important roles in cell membranes and lysenin is a popular SM-labeling reagent. The structure of lysenin suggests common ancestry with other pore-forming proteins from a diverse set of eukaryotes and prokaryotes. The complex with SM shows the mode of its recognition by a protein in which both the phosphocholine headgroup and one acyl tail are specifically bound. Lipid interaction studies and assays using viable target cells confirm the functional reliance of lysenin on this form of SM recognition.
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===Complex of lysenin with phosphocholine===
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Structures of lysenin reveal a shared evolutionary origin for pore-forming proteins and its mode of sphingomyelin recognition.,De Colibus L, Sonnen AF, Morris KJ, Siebert CA, Abrusci P, Plitzko J, Hodnik V, Leippe M, Volpi E, Anderluh G, Gilbert RJ Structure. 2012 Sep 5;20(9):1498-507. Epub 2012 Jul 19. PMID:22819216<ref>PMID:22819216</ref>
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{{ABSTRACT_PUBMED_22819216}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3zx7" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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[[3zx7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Eisenia_fetida Eisenia fetida]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZX7 OCA].
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*[[Cytolysin 3D structures|Cytolysin 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Eisenia fetida]]
[[Category: Eisenia fetida]]
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[[Category: Abrusci, P.]]
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[[Category: Large Structures]]
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[[Category: Anderluh, G.]]
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[[Category: Abrusci P]]
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[[Category: Colibus, L De.]]
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[[Category: Anderluh G]]
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[[Category: Gilbert, R J.C.]]
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[[Category: De Colibus L]]
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[[Category: Hodnik, V.]]
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[[Category: Gilbert RJC]]
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[[Category: Leippe, M.]]
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[[Category: Hodnik V]]
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[[Category: Morris, K J.]]
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[[Category: Leippe M]]
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[[Category: Plitzko, J.]]
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[[Category: Morris KJ]]
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[[Category: Siebert, C A.]]
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[[Category: Plitzko J]]
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[[Category: Sonnen, A F.P.]]
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[[Category: Siebert CA]]
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[[Category: Volpi, E.]]
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[[Category: Sonnen AFP]]
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[[Category: Pore forming toxin]]
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[[Category: Volpi E]]
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[[Category: Toxin]]
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Current revision

Complex of lysenin with phosphocholine

PDB ID 3zx7

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