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4g13

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[[Image:4g13.jpg|left|200px]]
 
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{{STRUCTURE_4g13| PDB=4g13 | SCENE= }}
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==Crystal structure of samarosporin I at 100K==
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<StructureSection load='4g13' size='340' side='right'caption='[[4g13]], [[Resolution|resolution]] 0.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4g13]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Samarospora_rostrup Samarospora rostrup]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G13 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G13 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=AIB:ALPHA-AMINOISOBUTYRIC+ACID'>AIB</scene>, <scene name='pdbligand=DIV:D-ISOVALINE'>DIV</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=PHL:L-PHENYLALANINOL'>PHL</scene>, <scene name='pdbligand=PRD_000920:SAMAROSPORIN+I'>PRD_000920</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g13 OCA], [https://pdbe.org/4g13 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g13 RCSB], [https://www.ebi.ac.uk/pdbsum/4g13 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g13 ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The atomic resolution structures of samarosporin I have been determined at 100 and 293 K. This is the first crystal structure of a natural 15-residue peptaibol. The amino acid sequence in samarosporin I is identical to emerimicin IV and stilbellin I. Samarosporin is a peptide antibiotic produced by the ascomycetous fungus Samarospora rostrup and belongs to peptaibol subfamily 2. The structures at both temperatures are very similar to each other adopting mainly a 3(10) -helical and a minor fraction of alpha-helical conformation. The helices are significantly bent and packed in an antiparallel fashion in the centered monoclinic lattice leaving among them an approximately 10-A channel extending along the crystallographic twofold axis. Only two ordered water molecules per peptide molecule were located in the channel. Comparisons have been carried out with crystal structures of subfamily 2 16-residue peptaibols antiamoebin and cephaibols. The repercussion of the structural analysis of samarosporin on membrane function is discussed. Copyright (c) 2012 European Peptide Society and John Wiley &amp; Sons, Ltd.
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===Crystal structure of samarosporin I at 100K===
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The crystal structure of samarosporin I at atomic resolution.,Gessmann R, Axford D, Evans G, Bruckner H, Petratos K J Pept Sci. 2012 Nov;18(11):678-84. doi: 10.1002/psc.2454. Epub 2012 Sep 28. PMID:23019149<ref>PMID:23019149</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==About this Structure==
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</div>
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[[4g13]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Samarospora_rostrup Samarospora rostrup]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G13 OCA].
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<div class="pdbe-citations 4g13" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Samarospora rostrup]]
[[Category: Samarospora rostrup]]
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[[Category: Axford, D.]]
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[[Category: Axford D]]
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[[Category: Gessmann, R.]]
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[[Category: Gessmann R]]
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[[Category: Petratos, K.]]
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[[Category: Petratos K]]
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[[Category: Antibiotic]]
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[[Category: Antibiotic peptide]]
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[[Category: Extracellular]]
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[[Category: Membrane]]
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[[Category: Peptaibol]]
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Current revision

Crystal structure of samarosporin I at 100K

PDB ID 4g13

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