3ua5

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[[Image:3ua5.png|left|200px]]
 
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{{STRUCTURE_3ua5| PDB=3ua5 | SCENE= }}
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==Crystal Structure of P450 2B6 (Y226H/K262R) in complex with two molecules of Amlodipine==
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<StructureSection load='3ua5' size='340' side='right'caption='[[3ua5]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3ua5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UA5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UA5 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=06X:AMLODIPINE'>06X</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ua5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ua5 OCA], [https://pdbe.org/3ua5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ua5 RCSB], [https://www.ebi.ac.uk/pdbsum/3ua5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ua5 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CP2B6_HUMAN CP2B6_HUMAN] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.<ref>PMID:11695850</ref>
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===Crystal Structure of P450 2B6 (Y226H/K262R) in complex with two molecules of Amlodipine===
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==See Also==
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*[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]]
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{{ABSTRACT_PUBMED_22909231}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[3ua5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UA5 OCA].
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Unspecific monooxygenase]]
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[[Category: Large Structures]]
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[[Category: Halpert, J R.]]
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[[Category: Halpert JR]]
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[[Category: Shah, M B.]]
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[[Category: Shah MB]]
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[[Category: Stout, C D.]]
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[[Category: Stout CD]]
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[[Category: Cyp 2b6]]
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[[Category: Human cytochrome p450 2b6]]
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[[Category: Membrane protein]]
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[[Category: Monooxygenase]]
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[[Category: Oxidoreductase]]
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[[Category: P450]]
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Current revision

Crystal Structure of P450 2B6 (Y226H/K262R) in complex with two molecules of Amlodipine

PDB ID 3ua5

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