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4ec3

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[[Image:4ec3.png|left|200px]]
 
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{{STRUCTURE_4ec3| PDB=4ec3 | SCENE= }}
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==Structure of berberine bridge enzyme, H174A variant in complex with (S)-reticuline==
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<StructureSection load='4ec3' size='340' side='right'caption='[[4ec3]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4ec3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Eschscholzia_californica Eschscholzia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EC3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EC3 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6501&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=REN:(S)-RETICULINE'>REN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ec3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ec3 OCA], [https://pdbe.org/4ec3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ec3 RCSB], [https://www.ebi.ac.uk/pdbsum/4ec3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ec3 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RETO_ESCCA RETO_ESCCA] Essential to the formation of benzophenanthridine alkaloids in the response of plants to pathogenic attack. Catalyzes the stereospecific conversion of the N-methyl moiety of (S)-reticuline into the berberine bridge carbon of (S)-scoulerine.
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===Structure of berberine bridge enzyme, H174A variant in complex with (S)-reticuline===
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==See Also==
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*[[Reticuline oxidase|Reticuline oxidase]]
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{{ABSTRACT_PUBMED_22757961}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[4ec3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Eschscholzia_californica Eschscholzia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EC3 OCA].
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==Reference==
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<ref group="xtra">PMID:022757961</ref><references group="xtra"/>
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[[Category: Eschscholzia californica]]
[[Category: Eschscholzia californica]]
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[[Category: Reticuline oxidase]]
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[[Category: Large Structures]]
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[[Category: Gruber, K.]]
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[[Category: Gruber K]]
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[[Category: Macheroux, P.]]
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[[Category: Macheroux P]]
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[[Category: Winkler, A.]]
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[[Category: Winkler A]]
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[[Category: Bi-covalent flavinylation]]
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[[Category: Fad]]
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[[Category: Oxidoreductase]]
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[[Category: P-cresol methyl hydroxylase superfamily]]
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Current revision

Structure of berberine bridge enzyme, H174A variant in complex with (S)-reticuline

PDB ID 4ec3

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