3ihr

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[[Image:3ihr.png|left|200px]]
 
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{{STRUCTURE_3ihr| PDB=3ihr | SCENE= }}
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==Crystal Structure of Uch37==
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<StructureSection load='3ihr' size='340' side='right'caption='[[3ihr]], [[Resolution|resolution]] 2.95&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3ihr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IHR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IHR FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ihr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ihr OCA], [https://pdbe.org/3ihr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ihr RCSB], [https://www.ebi.ac.uk/pdbsum/3ihr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ihr ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/UCHL5_HUMAN UCHL5_HUMAN] Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1.<ref>PMID:16906146</ref> <ref>PMID:18922472</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ih/3ihr_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ihr ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Uch37 is a de-ubiquitylating enzyme that is functionally linked with the 26S proteasome via Rpn13, and is essential for metazoan development. Here, we report the X-ray crystal structure of full-length human Uch37 at 2.95 A resolution. Uch37's catalytic domain is similar to those of all UCH enzymes characterized to date. The C-terminal extension is elongated, predominantly helical and contains coiled coil interactions. Additionally, we provide an initial characterization of Uch37's oligomeric state and identify a systematic error in previous analyses of Uch37 activity. Taken together, these data provide a strong foundation for further analysis of Uch37's several functions.
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===Crystal Structure of Uch37===
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Structural characterization of human Uch37.,Burgie SE, Bingman CA, Soni AB, Phillips GN Jr Proteins. 2012 Feb;80(2):649-54. doi: 10.1002/prot.23147. Epub 2011 Sep 26. PMID:21953935<ref>PMID:21953935</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3ihr" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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[[3ihr]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IHR OCA].
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*[[Thioesterase 3D structures|Thioesterase 3D structures]]
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[[Category: Ubiquitinyl hydrolase 1]]
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== References ==
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[[Category: Bingman, C A.]]
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<references/>
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[[Category: Burgie, E S.]]
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__TOC__
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[[Category: CESG, Center for Eukaryotic Structural Genomics.]]
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</StructureSection>
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[[Category: Phillips, G N.]]
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[[Category: Homo sapiens]]
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[[Category: Center for eukaryotic structural genomic]]
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[[Category: Large Structures]]
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[[Category: Cesg]]
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[[Category: Bingman CA]]
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[[Category: Homo sapien]]
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[[Category: Burgie ES]]
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[[Category: Hydrolase]]
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[[Category: Phillips Jr GN]]
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[[Category: Ino80]]
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[[Category: Protease]]
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[[Category: Proteasome]]
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[[Category: Protein structure initiative]]
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[[Category: Psi]]
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[[Category: Rpn13]]
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[[Category: Smad7]]
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[[Category: Structural genomic]]
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[[Category: Thiol protease]]
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[[Category: Ubiquitin]]
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[[Category: Ubiquitin hydrolase]]
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[[Category: Ubl conjugation pathway]]
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[[Category: Uch-l5]]
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[[Category: Uch37]]
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Current revision

Crystal Structure of Uch37

PDB ID 3ihr

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