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3nf5

From Proteopedia

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[[Image:3nf5.png|left|200px]]
 
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{{STRUCTURE_3nf5| PDB=3nf5 | SCENE= }}
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==Crystal structure of the C-terminal domain of nuclear pore complex component NUP116 from Candida glabrata==
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<StructureSection load='3nf5' size='340' side='right'caption='[[3nf5]], [[Resolution|resolution]] 1.94&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3nf5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_glabrata Candida glabrata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NF5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NF5 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.94&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nf5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nf5 OCA], [https://pdbe.org/3nf5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nf5 RCSB], [https://www.ebi.ac.uk/pdbsum/3nf5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nf5 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q6FU56_CANGA Q6FU56_CANGA]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nf/3nf5_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3nf5 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The nuclear pore complex (NPC), embedded in the nuclear envelope, is a large, dynamic molecular assembly that facilitates exchange of macromolecules between the nucleus and the cytoplasm. The yeast NPC is an eightfold symmetric annular structure composed of ~456 polypeptide chains contributed by ~30 distinct proteins termed nucleoporins. Nup116, identified only in fungi, plays a central role in both protein import and mRNA export through the NPC. Nup116 is a modular protein with N-terminal "FG" repeats containing a Gle2p-binding sequence motif and a NPC targeting domain at its C-terminus. We report the crystal structure of the NPC targeting domain of Candida glabrata Nup116, consisting of residues 882-1034 [CgNup116(882-1034)], at 1.94 A resolution. The X-ray structure of CgNup116(882-1034) is consistent with the molecular envelope determined in solution by small-angle X-ray scattering. Structural similarities of CgNup116(882-1034) with homologous domains from Saccharomyces cerevisiae Nup116, S. cerevisiae Nup145N, and human Nup98 are discussed.
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===Crystal structure of the C-terminal domain of nuclear pore complex component NUP116 from Candida glabrata===
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Atomic structure of the nuclear pore complex targeting domain of a Nup116 homologue from the yeast, Candida glabrata.,Sampathkumar P, Kim SJ, Manglicmot D, Bain KT, Gilmore J, Gheyi T, Phillips J, Pieper U, Fernandez-Martinez J, Franke JD, Matsui T, Tsuruta H, Atwell S, Thompson DA, Emtage JS, Wasserman SR, Rout MP, Sali A, Sauder JM, Almo SC, Burley SK Proteins. 2012 Aug;80(8):2110-6. doi: 10.1002/prot.24102. Epub 2012 Jun 4. PMID:22544723<ref>PMID:22544723</ref>
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{{ABSTRACT_PUBMED_22544723}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 3nf5" style="background-color:#fffaf0;"></div>
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[[3nf5]] is a 2 chain structure of [[Nucleoporin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NF5 OCA].
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==See Also==
==See Also==
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*[[Nucleoporin|Nucleoporin]]
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*[[Nucleoporin 3D structures|Nucleoporin 3D structures]]
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[[Category: Atwell, S.]]
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== References ==
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[[Category: Bain, K.]]
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<references/>
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[[Category: Burley, S K.]]
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__TOC__
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[[Category: Emtage, J S.]]
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</StructureSection>
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[[Category: Gheyi, T.]]
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[[Category: Large Structures]]
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[[Category: Gilmore, J.]]
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[[Category: Atwell S]]
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[[Category: Manglicmot, D.]]
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[[Category: Bain K]]
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[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics.]]
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[[Category: Burley SK]]
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[[Category: Rout, M.]]
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[[Category: Emtage JS]]
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[[Category: Sali, A.]]
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[[Category: Gheyi T]]
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[[Category: Sampathkumar, P.]]
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[[Category: Gilmore J]]
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[[Category: Sauder, J M.]]
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[[Category: Manglicmot D]]
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[[Category: Thompson, D A.]]
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[[Category: Rout M]]
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[[Category: Wasserman, S.]]
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[[Category: Sali A]]
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[[Category: Glebs domain]]
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[[Category: Sampathkumar P]]
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[[Category: New york sgx research center for structural genomic]]
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[[Category: Sauder JM]]
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[[Category: New york structural genomix research consortium]]
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[[Category: Thompson DA]]
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[[Category: Nuclear pore complex]]
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[[Category: Wasserman S]]
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[[Category: Nup116]]
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[[Category: Nysgxrc]]
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[[Category: Protein structure initiative]]
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[[Category: Protein transport]]
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[[Category: Psi-2]]
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[[Category: Structural genomic]]
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Current revision

Crystal structure of the C-terminal domain of nuclear pore complex component NUP116 from Candida glabrata

PDB ID 3nf5

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