This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4gid

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (15:47, 14 March 2024) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:4gid.jpg|left|200px]]
 
-
{{STRUCTURE_4gid| PDB=4gid | SCENE= }}
+
==Structure of beta-secretase complexed with inhibitor==
 +
<StructureSection load='4gid' size='340' side='right'caption='[[4gid]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[4gid]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GID OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GID FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0GH:N-[(2S)-1-({(2S,3R)-3-HYDROXY-1-[(2-METHYLPROPYL)AMINO]-1-OXOBUTAN-2-YL}AMINO)-3-PHENYLPROPAN-2-YL]-5-[METHYL(METHYLSULFONYL)AMINO]-N-[(1R)-1-PHENYLETHYL]BENZENE-1,3-DICARBOXAMIDE'>0GH</scene>, <scene name='pdbligand=LPD:L-PROLINAMIDE'>LPD</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gid OCA], [https://pdbe.org/4gid PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gid RCSB], [https://www.ebi.ac.uk/pdbsum/4gid PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gid ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
-
===Structure of beta-secretase complexed with inhibitor===
+
==See Also==
-
 
+
*[[Beta secretase 3D structures|Beta secretase 3D structures]]
-
{{ABSTRACT_PUBMED_22954357}}
+
== References ==
-
 
+
<references/>
-
==About this Structure==
+
__TOC__
-
[[4gid]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GID OCA].
+
</StructureSection>
-
[[Category: Memapsin 2]]
+
[[Category: Homo sapiens]]
-
[[Category: Anderson, D.]]
+
[[Category: Large Structures]]
-
[[Category: Gavande, N.]]
+
[[Category: Anderson D]]
-
[[Category: Ghosh, A.]]
+
[[Category: Gavande N]]
-
[[Category: Huang, X.]]
+
[[Category: Ghosh A]]
-
[[Category: Tang, J.]]
+
[[Category: Huang X]]
-
[[Category: Terzyan, S.]]
+
[[Category: Tang J]]
-
[[Category: Venkateswara, R K.]]
+
[[Category: Terzyan S]]
-
[[Category: Yadav, N.]]
+
[[Category: Venkateswara RK]]
-
[[Category: A-beta]]
+
[[Category: Yadav N]]
-
[[Category: Alzheimer]]
+
-
[[Category: App]]
+
-
[[Category: Aspartic protease]]
+
-
[[Category: Bace]]
+
-
[[Category: Beta secretase]]
+
-
[[Category: Drug design]]
+
-
[[Category: Hydrolase-hydrolase inhibitor complex]]
+
-
[[Category: Memapsin]]
+
-
[[Category: Protease]]
+

Current revision

Structure of beta-secretase complexed with inhibitor

PDB ID 4gid

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4gid"
Personal tools