3tkj

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[[Image:3tkj.jpg|left|200px]]
 
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{{STRUCTURE_3tkj| PDB=3tkj | SCENE= }}
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==Crystal Structure of Human Asparaginase-like Protein 1 Thr168Ala==
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<StructureSection load='3tkj' size='340' side='right'caption='[[3tkj]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3tkj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TKJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TKJ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TAM:TRIS(HYDROXYETHYL)AMINOMETHANE'>TAM</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tkj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tkj OCA], [https://pdbe.org/3tkj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tkj RCSB], [https://www.ebi.ac.uk/pdbsum/3tkj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tkj ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ASGL1_HUMAN ASGL1_HUMAN] Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L-Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine.<ref>PMID:19839645</ref>
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===Crystal Structure of Human Asparaginase-like Protein 1 Thr168Ala===
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==See Also==
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*[[Asparaginase 3D structures|Asparaginase 3D structures]]
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{{ABSTRACT_PUBMED_22891768}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[3tkj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TKJ OCA].
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</StructureSection>
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[[Category: Asparaginase]]
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[[Category: Homo sapiens]]
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[[Category: Li, W Z.]]
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[[Category: Large Structures]]
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[[Category: Liu, J.]]
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[[Category: Li WZ]]
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[[Category: Yogesha, S D.]]
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[[Category: Liu J]]
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[[Category: Zhang, Y.]]
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[[Category: Yogesha SD]]
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[[Category: Alpha-beta-beta-alpha]]
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[[Category: Zhang Y]]
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[[Category: Hydrolase]]
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Current revision

Crystal Structure of Human Asparaginase-like Protein 1 Thr168Ala

PDB ID 3tkj

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