Fibroins
From Proteopedia
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| - | Fibroins are proteins that constitute silk fibers. Fibroins are large complex proteins and the specific structural details of those making up different types of silk are different, but all fibroins have some common characteristics. Interesting general information on spider silk and a model of one type of a spider silk molecule is at<ref>[http://en.wikipedia.org/wiki/Spider_silk Wikipedia]</ref>. This model of spider silk shows two repeating domains that all fibroins contain. One domain is characterized as being amorphous, also called flexible, disordered segments, and the other one, symbolized by the boxes, has a highly ordered, repetitive, crystal-like structure. The objective of this exercise is to explicate this <b>ordered</b> domain of fibroins. | + | <StructureSection load='3ua0' size='350' side='right' caption='Silkworm fibroin N-terminal (PDB entry [[3ua0]])' scene=''> |
| + | '''Fibroins''' are proteins that constitute silk fibers<ref>PMID:15132657</ref>. Fibroins are large complex proteins and the specific structural details of those making up different types of silk are different, but all fibroins have some common characteristics. See also [[Fibrous Proteins]]. Interesting general information on spider silk and a model of one type of a spider silk molecule is at<ref>[http://en.wikipedia.org/wiki/Spider_silk Wikipedia]</ref>. This model of spider silk shows two repeating domains that all fibroins contain. One domain is characterized as being amorphous, also called flexible, disordered segments, and the other one, symbolized by the boxes, has a highly ordered, repetitive, crystal-like structure. The objective of this exercise is to explicate this <b>ordered</b> domain of <scene name='Fibroins/Chain_a/1'>fibroins</scene>. | ||
| - | <StructureSection load='fibroin.pdb' size='500' side='right' caption='Structure of a model fibroin' scene='Fibroins/Chain_a/1'> | ||
===Repetitive peptide segment & β-sheet=== | ===Repetitive peptide segment & β-sheet=== | ||
| - | Displayed here is a peptide segment that is present in many fibroin proteins that are found in silk fibers. | + | Displayed here is a peptide segment that is present in many fibroin proteins that are found in silk fibers. It is repeated many times to make up the ordered, repetitive structure of the crystalline domain of the fibroin. |
<Br> | <Br> | ||
Determine the sequence of the segment by hovering over the residues taking time to consider the nature of their side chains and from which direction their side chains project from the backbone. All the Gly need to be on the same side of the peptide in order to construct the silk fiber. Labels describe how <scene name='Fibroins/Chain_a_2/1'>hexapeptides are connected</scene> together to produce a longer polypeptide. | Determine the sequence of the segment by hovering over the residues taking time to consider the nature of their side chains and from which direction their side chains project from the backbone. All the Gly need to be on the same side of the peptide in order to construct the silk fiber. Labels describe how <scene name='Fibroins/Chain_a_2/1'>hexapeptides are connected</scene> together to produce a longer polypeptide. | ||
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Each wireframe chain <scene name='Fibroins/Multicolored/2'>colored differently</scene>. Show <scene name='Fibroins/Multicolored_2/2'>spacefill rendition</scene>. | Each wireframe chain <scene name='Fibroins/Multicolored/2'>colored differently</scene>. Show <scene name='Fibroins/Multicolored_2/2'>spacefill rendition</scene>. | ||
</StructureSection> | </StructureSection> | ||
| + | == 3D Structures of fibroin == | ||
| + | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
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| + | [[3ua0]] – Fib heavy chain – silkworm<br /> | ||
| + | [[2khm]], [[7vu7]] – Fib-3 C-terminal – spider - NMR<br /> | ||
| + | [[2m0m]] – NaFib-1 residues 250-356 – Nephila antipodiana - NMR<br /> | ||
| + | [[2mqa]] – NaFib-1 RP domain residues 32-163 - NMR<br /> | ||
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| + | == References == | ||
<references /> | <references /> | ||
| + | [[Category:Topic Page]] | ||
Current revision
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3D Structures of fibroin
Updated on 03-July-2025
3ua0 – Fib heavy chain – silkworm
2khm, 7vu7 – Fib-3 C-terminal – spider - NMR
2m0m – NaFib-1 residues 250-356 – Nephila antipodiana - NMR
2mqa – NaFib-1 RP domain residues 32-163 - NMR
References
- ↑ Sohn S, Strey HH, Gido SP. Phase behavior and hydration of silk fibroin. Biomacromolecules. 2004 May-Jun;5(3):751-7. PMID:15132657 doi:http://dx.doi.org/10.1021/bm0343693
- ↑ Wikipedia
