4atp
From Proteopedia
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| - | [[Image:4atp.png|left|200px]] | ||
| - | + | ==Structure of GABA-transaminase A1R958 from Arthrobacter aurescens in complex with PLP== | |
| + | <StructureSection load='4atp' size='340' side='right'caption='[[4atp]], [[Resolution|resolution]] 2.80Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4atp]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Paenarthrobacter_aurescens_TC1 Paenarthrobacter aurescens TC1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ATP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ATP FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4atp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4atp OCA], [https://pdbe.org/4atp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4atp RCSB], [https://www.ebi.ac.uk/pdbsum/4atp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4atp ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A1R958_PAEAT A1R958_PAEAT] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Two complex structures of the gamma-aminobutyrate (GABA) transaminase A1R958 from Arthrobacter aurescens TC1 are presented. The first, determined to a resolution of 2.80 A, features the internal aldimine formed by reaction between the -amino group of Lys295 and the cofactor pyridoxal phosphate (PLP); the second, determined to a resolution of 2.75 A, features the external aldimine adduct formed between PLP and GABA in the first half-reaction. This is the first structure of a microbial GABA transaminase in complex with its natural external aldimine and reveals the molecular determinants of GABA binding in this enzyme. | ||
| - | + | Structures of a gamma-aminobutyrate (GABA) transaminase from the s-triazine-degrading organism Arthrobacter aurescens TC1 in complex with PLP and with its external aldimine PLP-GABA adduct.,Bruce H, Nguyen Tuan A, Mangas Sanchez J, Leese C, Hopwood J, Hyde R, Hart S, Turkenburg JP, Grogan G Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Oct 1;68(Pt 10):1175-80., doi: 10.1107/S1744309112030023. Epub 2012 Sep 29. PMID:23027742<ref>PMID:23027742</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | == | + | <div class="pdbe-citations 4atp" style="background-color:#fffaf0;"></div> |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: Bruce | + | </StructureSection> |
| - | [[Category: Grogan | + | [[Category: Large Structures]] |
| - | [[Category: Hart | + | [[Category: Paenarthrobacter aurescens TC1]] |
| - | [[Category: Sanchez | + | [[Category: Bruce H]] |
| - | [[Category: Tuan | + | [[Category: Grogan G]] |
| - | [[Category: Turkenburg | + | [[Category: Hart S]] |
| - | + | [[Category: Mangas Sanchez J]] | |
| + | [[Category: Tuan AN]] | ||
| + | [[Category: Turkenburg JP]] | ||
Current revision
Structure of GABA-transaminase A1R958 from Arthrobacter aurescens in complex with PLP
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