4efs

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[[Image:4efs.png|left|200px]]
 
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{{STRUCTURE_4efs| PDB=4efs | SCENE= }}
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==Human MMP12 in complex with L-glutamate motif inhibitor==
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<StructureSection load='4efs' size='340' side='right'caption='[[4efs]], [[Resolution|resolution]] 1.63&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4efs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EFS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EFS FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.63&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=E37:N~2~-[4-(4-PHENYLTHIOPHEN-2-YL)BENZOYL]-L-ALPHA-GLUTAMINE'>E37</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=PGO:S-1,2-PROPANEDIOL'>PGO</scene>, <scene name='pdbligand=PGR:R-1,2-PROPANEDIOL'>PGR</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4efs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4efs OCA], [https://pdbe.org/4efs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4efs RCSB], [https://www.ebi.ac.uk/pdbsum/4efs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4efs ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MMP12_HUMAN MMP12_HUMAN] May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.
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===Human MMP12 in complex with L-glutamate motif inhibitor===
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==See Also==
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*[[Matrix metalloproteinase 3D structures|Matrix metalloproteinase 3D structures]]
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{{ABSTRACT_PUBMED_22689580}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[4efs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EFS OCA].
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Macrophage elastase]]
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[[Category: Large Structures]]
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[[Category: Beau, F.]]
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[[Category: Beau F]]
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[[Category: Czarny, B.]]
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[[Category: Czarny B]]
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[[Category: Devel, L.]]
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[[Category: Devel L]]
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[[Category: Dive, V.]]
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[[Category: Dive V]]
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[[Category: Stura, E A.]]
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[[Category: Stura EA]]
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[[Category: Vera, L.]]
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[[Category: Vera L]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: L-glutamate motif inhibitor]]
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[[Category: Metzincin]]
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[[Category: Potent inhibitor]]
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[[Category: Pseudo peptide]]
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[[Category: Zinc protease]]
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Current revision

Human MMP12 in complex with L-glutamate motif inhibitor

PDB ID 4efs

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