4fix

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[[Image:4fix.png|left|200px]]
 
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{{STRUCTURE_4fix| PDB=4fix | SCENE= }}
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==Crystal Structure of GlfT2==
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<StructureSection load='4fix' size='340' side='right'caption='[[4fix]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
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===Crystal Structure of GlfT2===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4fix]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FIX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FIX FirstGlance]. <br>
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{{ABSTRACT_PUBMED_22707726}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fix FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fix OCA], [https://pdbe.org/4fix PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fix RCSB], [https://www.ebi.ac.uk/pdbsum/4fix PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fix ProSAT]</span></td></tr>
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[[4fix]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_h37rv Mycobacterium tuberculosis h37rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FIX OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/GLFT2_MYCTU GLFT2_MYCTU] Involved in the polymerization of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacteria cell wall, through successively beta-D-(1->5) and beta-D-(1->6)-galactofuranosyltransferases activities. It transfers the galactofuranosyl (Galf) unit from UDP-galactofuranosyl (UDP-Galf) onto the galactofuranosyl-rhamnosyl-GlcNAc-pyrophosphoryl-undecaprenyl (Galf-Rha-GlcNAc-PP-C55), yielding polygalactofuranosyl-rhamnosyl-GlcNAc-pyrophosphoryl-undecaprenyl ((Galf)x-Rha-GlcNAc-PP-C55). It is able to transfer Galf onto beta-D-(1->5) or beta-D-(1->6) linked acceptor, but has a stronger affinity for beta-D-(1->6) acceptor.<ref>PMID:10934214</ref> <ref>PMID:11304545</ref> <ref>PMID:16704275</ref> <ref>PMID:18055597</ref> <ref>PMID:18423586</ref> <ref>PMID:19571009</ref>
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<ref group="xtra">PMID:022707726</ref><references group="xtra"/>
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== References ==
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[[Category: Mycobacterium tuberculosis h37rv]]
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<references/>
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[[Category: Lowary, T L.]]
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__TOC__
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[[Category: Ng, K K.S.]]
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</StructureSection>
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[[Category: Wheatley, R W.]]
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[[Category: Large Structures]]
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[[Category: Zheng, R B.]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Carbohydrate binding]]
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[[Category: Lowary TL]]
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[[Category: Cazy gt-2 family]]
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[[Category: Ng KKS]]
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[[Category: Galactofuranosyltransferase]]
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[[Category: Wheatley RW]]
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[[Category: Glycosyltransferase]]
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[[Category: Zheng RB]]
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[[Category: Membrane]]
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[[Category: Transferase]]
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Current revision

Crystal Structure of GlfT2

PDB ID 4fix

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