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4hc7

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'''Unreleased structure'''
 
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The entry 4hc7 is ON HOLD
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==Crystal structure of the full DNA binding domain of GATA3-complex 2==
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<StructureSection load='4hc7' size='340' side='right'caption='[[4hc7]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
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Authors: Chen, Y., Bates, D.L., Dey, R., Chen, L.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4hc7]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HC7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HC7 FirstGlance]. <br>
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Description: Crystal structure of the full DNA binding domain of GATA3-complex 2
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hc7 OCA], [https://pdbe.org/4hc7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hc7 RCSB], [https://www.ebi.ac.uk/pdbsum/4hc7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hc7 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/GATA3_HUMAN GATA3_HUMAN] Precursor B-cell acute lymphoblastic leukemia;Hypoparathyroidism - deafness - renal disease. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/GATA3_HUMAN GATA3_HUMAN] Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses.<ref>PMID:23824597</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Bates DL]]
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[[Category: Chen L]]
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[[Category: Chen Y]]
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[[Category: Dey R]]

Current revision

Crystal structure of the full DNA binding domain of GATA3-complex 2

PDB ID 4hc7

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