4ekg

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[[Image:4ekg.jpg|left|200px]]
 
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{{STRUCTURE_4ekg| PDB=4ekg | SCENE= }}
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==Crystal Structure of DOT1L in Complex with EPZ003696==
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<StructureSection load='4ekg' size='340' side='right'caption='[[4ekg]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4ekg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EKG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EKG FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0QJ:5-[(3-{[(4-TERT-BUTYLPHENYL)CARBAMOYL]AMINO}PROPYL)(METHYL)AMINO]-5-DEOXYADENOSINE'>0QJ</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ekg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ekg OCA], [https://pdbe.org/4ekg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ekg RCSB], [https://www.ebi.ac.uk/pdbsum/4ekg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ekg ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DOT1L_HUMAN DOT1L_HUMAN] Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA.
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===Crystal Structure of DOT1L in Complex with EPZ003696===
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==See Also==
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*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]]
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{{ABSTRACT_PUBMED_22978415}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[4ekg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EKG OCA].
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[[Category: Histone-lysine N-methyltransferase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Jin, L.]]
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[[Category: Large Structures]]
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[[Category: Methyltransferase]]
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[[Category: Jin L]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

Crystal Structure of DOT1L in Complex with EPZ003696

PDB ID 4ekg

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