4f97
From Proteopedia
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| - | [[Image:4f97.jpg|left|200px]] | ||
| - | + | ==Crystal Structure of VldE, the pseudo-glycosyltransferase, in complex with GDP and validoxylamine A 7'-phosphate== | |
| + | <StructureSection load='4f97' size='340' side='right'caption='[[4f97]], [[Resolution|resolution]] 2.11Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4f97]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_hygroscopicus_subsp._limoneus Streptomyces hygroscopicus subsp. limoneus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F97 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4F97 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.108Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=VDO:[(1R,2R,3S,4S,5S)-2,3,4-TRIHYDROXY-5-{[(1S,4R,5S,6S)-4,5,6-TRIHYDROXY-3-(HYDROXYMETHYL)CYCLOHEX-2-EN-1-YL]AMINO}CYCLOHEXYL]METHYL+DIHYDROGEN+PHOSPHATE'>VDO</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4f97 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f97 OCA], [https://pdbe.org/4f97 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4f97 RCSB], [https://www.ebi.ac.uk/pdbsum/4f97 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4f97 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/VLDE_STRHL VLDE_STRHL] Involved in the biosynthesis of the antifungal agent validamycin A (PubMed:16725283). Catalyzes the condensation between GDP-valienol and validamine 7-phosphate via a nonglycosidic C-N bond formation to yield validoxylamine A 7'-phosphate (PubMed:21766819).<ref>PMID:16725283</ref> <ref>PMID:21766819</ref> | ||
| - | == | + | ==See Also== |
| - | + | *[[Glycosyltransferase 3D structures|Glycosyltransferase 3D structures]] | |
| - | + | == References == | |
| - | + | <references/> | |
| - | == | + | __TOC__ |
| - | [[ | + | </StructureSection> |
| + | [[Category: Large Structures]] | ||
[[Category: Streptomyces hygroscopicus subsp. limoneus]] | [[Category: Streptomyces hygroscopicus subsp. limoneus]] | ||
| - | [[Category: Almabruk | + | [[Category: Almabruk KH]] |
| - | [[Category: Asamizu | + | [[Category: Asamizu S]] |
| - | [[Category: Cavalier | + | [[Category: Cavalier MC]] |
| - | [[Category: Lee | + | [[Category: Lee Y-H]] |
| - | [[Category: Mahmud | + | [[Category: Mahmud T]] |
| - | [[Category: Neau | + | [[Category: Neau D]] |
| - | [[Category: Yim | + | [[Category: Yim Y-S]] |
| - | + | ||
| - | + | ||
Current revision
Crystal Structure of VldE, the pseudo-glycosyltransferase, in complex with GDP and validoxylamine A 7'-phosphate
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