1kxg

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[[Image:1kxg.gif|left|200px]]<br /><applet load="1kxg" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1kxg, resolution 2.00&Aring;" />
 
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'''The 2.0 Ang Resolution Structure of BLyS, B Lymphocyte Stimulator.'''<br />
 
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==Overview==
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==The 2.0 Ang Resolution Structure of BLyS, B Lymphocyte Stimulator.==
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<StructureSection load='1kxg' size='340' side='right'caption='[[1kxg]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1kxg]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KXG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KXG FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kxg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kxg OCA], [https://pdbe.org/1kxg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kxg RCSB], [https://www.ebi.ac.uk/pdbsum/1kxg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kxg ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TN13B_HUMAN TN13B_HUMAN] Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.<ref>PMID:10973284</ref> Isoform 2 seems to inhibit isoform 1 secretion and bioactivity (By similarity).<ref>PMID:10973284</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kx/1kxg_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kxg ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
B lymphocyte stimulator (BLyS), a member of the tumor necrosis factor (TNF) superfamily, is a cytokine that induces B-cell proliferation and immunoglobulin secretion. We have determined the three-dimensional structure of BLyS to 2.0 A resolution and identified receptor recognition segments using limited proteolysis coupled with mass spectrometry. Similar to other structurally determined TNF-like ligands, the BLyS monomer is a beta-sandwich and oligomerizes to form a homotrimer. The receptor-binding region in BLyS is a deeper, more pronounced groove than in other cytokines. The conserved elements on the 'floor' of this groove allow for cytokine recognition of several structurally related receptors, whereas variations on the 'walls' and outer rims of the groove confer receptor specificity.
B lymphocyte stimulator (BLyS), a member of the tumor necrosis factor (TNF) superfamily, is a cytokine that induces B-cell proliferation and immunoglobulin secretion. We have determined the three-dimensional structure of BLyS to 2.0 A resolution and identified receptor recognition segments using limited proteolysis coupled with mass spectrometry. Similar to other structurally determined TNF-like ligands, the BLyS monomer is a beta-sandwich and oligomerizes to form a homotrimer. The receptor-binding region in BLyS is a deeper, more pronounced groove than in other cytokines. The conserved elements on the 'floor' of this groove allow for cytokine recognition of several structurally related receptors, whereas variations on the 'walls' and outer rims of the groove confer receptor specificity.
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==About this Structure==
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Structural basis of BLyS receptor recognition.,Oren DA, Li Y, Volovik Y, Morris TS, Dharia C, Das K, Galperina O, Gentz R, Arnold E Nat Struct Biol. 2002 Apr;9(4):288-92. PMID:11862220<ref>PMID:11862220</ref>
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1KXG is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=CIT:'>CIT</scene> and <scene name='pdbligand=DIO:'>DIO</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KXG OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Structural basis of BLyS receptor recognition., Oren DA, Li Y, Volovik Y, Morris TS, Dharia C, Das K, Galperina O, Gentz R, Arnold E, Nat Struct Biol. 2002 Apr;9(4):288-92. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11862220 11862220]
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</div>
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[[Category: Homo sapiens]]
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<div class="pdbe-citations 1kxg" style="background-color:#fffaf0;"></div>
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[[Category: Single protein]]
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[[Category: Arnold, E.]]
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[[Category: Das, K.]]
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[[Category: Dharia, C.]]
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[[Category: Galperina, O.]]
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[[Category: Gentz, R.]]
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[[Category: Li, Y.]]
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[[Category: Morris, T S.]]
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[[Category: Oren, D A.]]
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[[Category: Volovik, Y.]]
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[[Category: CIT]]
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[[Category: DIO]]
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[[Category: MG]]
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[[Category: baff]]
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[[Category: beta-sandwich]]
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[[Category: cytokine]]
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[[Category: jellyroll]]
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[[Category: tall-1]]
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[[Category: thank]]
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[[Category: tnf superfamily]]
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[[Category: ztnf4]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:39:02 2008''
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==See Also==
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*[[Tumor necrosis factor receptor 3D structures|Tumor necrosis factor receptor 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Arnold E]]
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[[Category: Das K]]
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[[Category: Dharia C]]
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[[Category: Galperina O]]
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[[Category: Gentz R]]
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[[Category: Li Y]]
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[[Category: Morris TS]]
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[[Category: Oren DA]]
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[[Category: Volovik Y]]

Current revision

The 2.0 Ang Resolution Structure of BLyS, B Lymphocyte Stimulator.

PDB ID 1kxg

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