1cfc

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:21, 22 May 2024) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1cfc.png|left|200px]]
 
-
{{STRUCTURE_1cfc| PDB=1cfc | SCENE= }}
+
==CALCIUM-FREE CALMODULIN==
 +
<StructureSection load='1cfc' size='340' side='right'caption='[[1cfc]]' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[1cfc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CFC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CFC FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cfc OCA], [https://pdbe.org/1cfc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cfc RCSB], [https://www.ebi.ac.uk/pdbsum/1cfc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cfc ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/CALM1_XENLA CALM1_XENLA] Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cf/1cfc_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cfc ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The three-dimensional structure of calmodulin in the absence of Ca2+ has been determined by three- and four-dimensional heteronuclear NMR experiments, including ROE, isotope-filtering combined with reverse labelling, and measurement of more than 700 three-bond J-couplings. In analogy with the Ca(2+)-ligated state of this protein, it consists of two small globular domains separated by a flexible linker, with no stable, direct contacts between the two domains. In the absence of Ca2+, the four helices in each of the two globular domains form a highly twisted bundle, capped by a short anti-parallel beta-sheet. This arrangement is qualitatively similar to that observed in the crystal structure of the Ca(2+)-free N-terminal domain of troponin C.
-
===CALCIUM-FREE CALMODULIN===
+
Solution structure of calcium-free calmodulin.,Kuboniwa H, Tjandra N, Grzesiek S, Ren H, Klee CB, Bax A Nat Struct Biol. 1995 Sep;2(9):768-76. PMID:7552748<ref>PMID:7552748</ref>
-
{{ABSTRACT_PUBMED_7552748}}
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
 
+
</div>
-
==About this Structure==
+
<div class="pdbe-citations 1cfc" style="background-color:#fffaf0;"></div>
-
[[1cfc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CFC OCA].
+
==See Also==
==See Also==
-
*[[Calmodulin|Calmodulin]]
+
*[[Calmodulin 3D structures|Calmodulin 3D structures]]
*[[Hydrogen in macromolecular models|Hydrogen in macromolecular models]]
*[[Hydrogen in macromolecular models|Hydrogen in macromolecular models]]
-
*[[NMR Ensembles of Models|NMR Ensembles of Models]]
+
== References ==
-
*[[Structural alignment tools|Structural alignment tools]]
+
<references/>
-
 
+
__TOC__
-
==Reference==
+
</StructureSection>
-
<ref group="xtra">PMID:007552748</ref><references group="xtra"/>
+
[[Category: Large Structures]]
[[Category: Xenopus laevis]]
[[Category: Xenopus laevis]]
-
[[Category: Bax, A.]]
+
[[Category: Bax A]]
-
[[Category: Grzesiek, S.]]
+
[[Category: Grzesiek S]]
-
[[Category: Klee, C B.]]
+
[[Category: Klee CB]]
-
[[Category: Kuboniwa, H.]]
+
[[Category: Kuboniwa H]]
-
[[Category: Ren, H.]]
+
[[Category: Ren H]]
-
[[Category: Tjandra, N.]]
+
[[Category: Tjandra N]]
-
[[Category: Calcium-binding protein]]
+

Current revision

CALCIUM-FREE CALMODULIN

PDB ID 1cfc

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1cfc"
Personal tools