3oki

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[[Image:3oki.png|left|200px]]
 
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{{STRUCTURE_3oki| PDB=3oki | SCENE= }}
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==Crystal structure of human FXR in complex with (2S)-2-[2-(4-chlorophenyl)-1H-benzimidazol-1-yl]-N,2-dicyclohexylethanamide==
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<StructureSection load='3oki' size='340' side='right'caption='[[3oki]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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===Crystal structure of human FXR in complex with (2S)-2-[2-(4-chlorophenyl)-1H-benzimidazol-1-yl]-N,2-dicyclohexylethanamide===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3oki]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OKI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OKI FirstGlance]. <br>
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{{ABSTRACT_PUBMED_21134747}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OKI:(2S)-2-[2-(4-CHLOROPHENYL)-1H-BENZIMIDAZOL-1-YL]-N,2-DICYCLOHEXYLETHANAMIDE'>OKI</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3oki FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oki OCA], [https://pdbe.org/3oki PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3oki RCSB], [https://www.ebi.ac.uk/pdbsum/3oki PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3oki ProSAT]</span></td></tr>
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[[3oki]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OKI OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NR1H4_HUMAN NR1H4_HUMAN] Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.<ref>PMID:10334992</ref> <ref>PMID:10334993</ref> <ref>PMID:12815072</ref> <ref>PMID:15471871</ref> <ref>PMID:12718892</ref> <ref>PMID:18621523</ref> <ref>PMID:19410460</ref> <ref>PMID:19586769</ref>
==See Also==
==See Also==
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*[[Hormone|Hormone]]
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*[[Bile acid receptor 3D structures|Bile acid receptor 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:021134747</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Rudolph, M G.]]
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[[Category: Large Structures]]
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[[Category: Bile acid]]
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[[Category: Rudolph MG]]
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[[Category: Cholesterol]]
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[[Category: Coactivator]]
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[[Category: Dna-binding]]
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[[Category: Fxr alternative splicing]]
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[[Category: Hormone receptor]]
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[[Category: Ligand binding domain transcription regulation]]
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[[Category: Nuclear receptor]]
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[[Category: Nucleus]]
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[[Category: Receptor]]
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[[Category: Transcription]]
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Current revision

Crystal structure of human FXR in complex with (2S)-2-[2-(4-chlorophenyl)-1H-benzimidazol-1-yl]-N,2-dicyclohexylethanamide

PDB ID 3oki

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