2vim
From Proteopedia
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| - | [[Image:2vim.png|left|200px]] | ||
| - | + | ==X-ray structure of Fasciola hepatica thioredoxin== | |
| + | <StructureSection load='2vim' size='340' side='right'caption='[[2vim]], [[Resolution|resolution]] 1.38Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2vim]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Fasciola_hepatica Fasciola hepatica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VIM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VIM FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.38Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vim OCA], [https://pdbe.org/2vim PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vim RCSB], [https://www.ebi.ac.uk/pdbsum/2vim PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vim ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q9U1G7_FASHE Q9U1G7_FASHE] | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vi/2vim_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vim ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The Fasciola hepatica thioredoxin protein structure has been determined to 1.45A resolution. This is the first example of a single crystal structure to show the active site cysteine residues in both the reduced and disulfide oxidised form. Consistent with this observation the process of oxidation appears to require very little rearrangement of the surrounding protein structure. The F. hepatica thioredoxin structure has been compared to other thioredoxin protein structures already known and is found to be highly conserved. The F. hepatica protein is most similar to that of the thioredoxin from its human and animal hosts but it resembles other parasitic thioredoxins with regard to having no additional cysteine residues and is therefore not regulated by transient disulfide bond formation as proposed for thioredoxins from higher eukaryotic species. | ||
| - | + | The Fasciola hepatica thioredoxin: High resolution structure reveals two oxidation states.,Line K, Isupov MN, Garcia-Rodriguez E, Maggioli G, Parra F, Littlechild JA Mol Biochem Parasitol. 2008 Sep;161(1):44-8. Epub 2008 Jun 21. PMID:18620002<ref>PMID:18620002</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 2vim" style="background-color:#fffaf0;"></div> | |
| - | + | ||
==See Also== | ==See Also== | ||
| - | *[[Thioredoxin|Thioredoxin]] | + | *[[Art:Thioredoxin: A small protein with a radical role|Art:Thioredoxin: A small protein with a radical role]] |
| - | + | *[[Thioredoxin 3D structures|Thioredoxin 3D structures]] | |
| - | == | + | == References == |
| - | < | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Fasciola hepatica]] | [[Category: Fasciola hepatica]] | ||
| - | [[Category: Garcia-Rodriguez | + | [[Category: Large Structures]] |
| - | [[Category: Isupov | + | [[Category: Garcia-Rodriguez E]] |
| - | [[Category: Line | + | [[Category: Isupov MN]] |
| - | [[Category: Littlechild | + | [[Category: Line K]] |
| - | [[Category: Maggioli | + | [[Category: Littlechild JA]] |
| - | [[Category: Parra | + | [[Category: Maggioli G]] |
| - | + | [[Category: Parra F]] | |
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
X-ray structure of Fasciola hepatica thioredoxin
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