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1imx

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[[Image:1imx.png|left|200px]]
 
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{{STRUCTURE_1imx| PDB=1imx | SCENE= }}
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==1.8 Angstrom crystal structure of IGF-1==
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<StructureSection load='1imx' size='340' side='right'caption='[[1imx]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
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===1.8 Angstrom crystal structure of IGF-1===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1imx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IMX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IMX FirstGlance]. <br>
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{{ABSTRACT_PUBMED_11551198}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.82&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=CPQ:N,N-BIS(3-D-GLUCONAMIDOPROPYL)DEOXYCHOLAMIDE'>CPQ</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1imx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1imx OCA], [https://pdbe.org/1imx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1imx RCSB], [https://www.ebi.ac.uk/pdbsum/1imx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1imx ProSAT]</span></td></tr>
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[[1imx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IMX OCA].
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/IGF1_HUMAN IGF1_HUMAN] Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:[https://omim.org/entry/608747 608747]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.
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== Function ==
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[https://www.uniprot.org/uniprot/IGF1_HUMAN IGF1_HUMAN] The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake.<ref>PMID:21076856</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/im/1imx_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1imx ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
*[[Insulin-like growth factor|Insulin-like growth factor]]
*[[Insulin-like growth factor|Insulin-like growth factor]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:011551198</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Deshayes, K D.]]
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[[Category: Large Structures]]
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[[Category: Liu, J.]]
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[[Category: Deshayes KD]]
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[[Category: Schaffer, M L.]]
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[[Category: Liu J]]
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[[Category: Skelton, N J.]]
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[[Category: Schaffer ML]]
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[[Category: Ultsch, M.]]
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[[Category: Skelton NJ]]
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[[Category: Vajdos, F F.]]
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[[Category: Ultsch M]]
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[[Category: Vos, A M.de.]]
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[[Category: Vajdos FF]]
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[[Category: Detergent]]
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[[Category: De Vos AM]]
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[[Category: Hormone-growth factor complex]]
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[[Category: Insulin/relaxin]]
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Current revision

1.8 Angstrom crystal structure of IGF-1

PDB ID 1imx

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