1k01
From Proteopedia
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| - | [[Image:1k01.png|left|200px]] | ||
| - | + | ==Structural Basis for the Interaction of Antibiotics with the Peptidyl Transferase Center in Eubacteria== | |
| - | + | <StructureSection load='1k01' size='340' side='right'caption='[[1k01]], [[Resolution|resolution]] 3.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1k01]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K01 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K01 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLM:CHLORAMPHENICOL'>CLM</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k01 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k01 OCA], [https://pdbe.org/1k01 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k01 RCSB], [https://www.ebi.ac.uk/pdbsum/1k01 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k01 ProSAT]</span></td></tr> |
| - | [[1k01]] is a 4 chain structure with sequence from [ | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/RL4_DEIRA RL4_DEIRA] One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly (By similarity).[HAMAP-Rule:MF_01328_B] Makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit.[HAMAP-Rule:MF_01328_B] This protein is located close to the polypeptide exit tunnel, and interacts with the modified macrolide azithromycin, which blocks the tunnel.[HAMAP-Rule:MF_01328_B] | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k0/1k01_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1k01 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
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*[[Ribosomal protein L32|Ribosomal protein L32]] | *[[Ribosomal protein L32|Ribosomal protein L32]] | ||
*[[Ribosomal protein L4|Ribosomal protein L4]] | *[[Ribosomal protein L4|Ribosomal protein L4]] | ||
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
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[[Category: Deinococcus radiodurans]] | [[Category: Deinococcus radiodurans]] | ||
| - | [[Category: Albrecht | + | [[Category: Large Structures]] |
| - | [[Category: Bashan | + | [[Category: Albrecht R]] |
| - | [[Category: Franceschi | + | [[Category: Bashan A]] |
| - | [[Category: Harms | + | [[Category: Franceschi F]] |
| - | [[Category: Schluenzen | + | [[Category: Harms J]] |
| - | [[Category: Tocilj | + | [[Category: Schluenzen F]] |
| - | [[Category: Yonath | + | [[Category: Tocilj A]] |
| - | [[Category: Zarivach | + | [[Category: Yonath A]] |
| - | + | [[Category: Zarivach R]] | |
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Current revision
Structural Basis for the Interaction of Antibiotics with the Peptidyl Transferase Center in Eubacteria
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