2r5i
From Proteopedia
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| - | [[Image:2r5i.png|left|200px]] | ||
| - | + | ==Pentamer Structure of Major Capsid Protein L1 of Human Papilloma Virus type 18== | |
| - | + | <StructureSection load='2r5i' size='340' side='right'caption='[[2r5i]], [[Resolution|resolution]] 3.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2r5i]] is a 15 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_papillomavirus_type_18 Human papillomavirus type 18]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R5I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R5I FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r5i OCA], [https://pdbe.org/2r5i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r5i RCSB], [https://www.ebi.ac.uk/pdbsum/2r5i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r5i ProSAT]</span></td></tr> | |
| - | == | + | </table> |
| - | [[2r5i]] is a 15 chain structure with sequence from [ | + | == Function == |
| + | [https://www.uniprot.org/uniprot/VL1_HPV18 VL1_HPV18] Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.[HAMAP-Rule:MF_04002] | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r5/2r5i_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r5i ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Virus coat | + | *[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]] |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
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[[Category: Human papillomavirus type 18]] | [[Category: Human papillomavirus type 18]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Bishop B]] |
| - | [[Category: | + | [[Category: Chen XS]] |
| - | [[Category: | + | [[Category: Dasgupta J]] |
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Current revision
Pentamer Structure of Major Capsid Protein L1 of Human Papilloma Virus type 18
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