3tf2

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (13:26, 14 March 2024) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3tf2.png|left|200px]]
 
-
{{STRUCTURE_3tf2| PDB=3tf2 | SCENE= }}
+
==Crystal structure of the cap free human translation initiation factor eIF4E==
-
 
+
<StructureSection load='3tf2' size='340' side='right'caption='[[3tf2]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-
===Crystal structure of the cap free human translation initiation factor eIF4E===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[3tf2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TF2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TF2 FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_22178476}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tf2 OCA], [https://pdbe.org/3tf2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tf2 RCSB], [https://www.ebi.ac.uk/pdbsum/3tf2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tf2 ProSAT]</span></td></tr>
-
[[3tf2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TF2 OCA].
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/IF4E_HUMAN IF4E_HUMAN] Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1 (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.<ref>PMID:16271312</ref>
==See Also==
==See Also==
-
*[[Eukaryotic initiation factor|Eukaryotic initiation factor]]
+
*[[Eukaryotic initiation factor 3D structures|Eukaryotic initiation factor 3D structures]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<ref group="xtra">PMID:022178476</ref><references group="xtra"/>
+
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Arrowsmith, C H.]]
+
[[Category: Large Structures]]
-
[[Category: Borden, K L.B.]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Bountra, C.]]
+
[[Category: Borden KLB]]
-
[[Category: Edwards, A M.]]
+
[[Category: Bountra C]]
-
[[Category: Nedyalkova, L.]]
+
[[Category: Edwards AM]]
-
[[Category: Park, H.]]
+
[[Category: Nedyalkova L]]
-
[[Category: SGC, Structural Genomics Consortium.]]
+
[[Category: Park H]]
-
[[Category: Siddiqui, N.]]
+
[[Category: Siddiqui N]]
-
[[Category: Tempel, W.]]
+
[[Category: Tempel W]]
-
[[Category: Weigelt, J.]]
+
[[Category: Weigelt J]]
-
[[Category: Wernimont, A K.]]
+
[[Category: Wernimont AK]]
-
[[Category: Eif4e]]
+
-
[[Category: Mrna export]]
+
-
[[Category: Sgc]]
+
-
[[Category: Structural genomic]]
+
-
[[Category: Structural genomics consortium]]
+
-
[[Category: Translation]]
+

Current revision

Crystal structure of the cap free human translation initiation factor eIF4E

PDB ID 3tf2

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3tf2"
Personal tools