3nw2

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[[Image:3nw2.png|left|200px]]
 
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{{STRUCTURE_3nw2| PDB=3nw2 | SCENE= }}
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==Novel nanomolar Imidazopyridines as selective Nitric Oxide Synthase (iNOS) inhibitors: SAR and structural insights==
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<StructureSection load='3nw2' size='340' side='right'caption='[[3nw2]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3nw2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NW2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NW2 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MPW:2-[2-(4-METHOXYPYRIDIN-2-YL)ETHYL]-3H-IMIDAZO[4,5-B]PYRIDINE'>MPW</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nw2 OCA], [https://pdbe.org/3nw2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nw2 RCSB], [https://www.ebi.ac.uk/pdbsum/3nw2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nw2 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NOS2_MOUSE NOS2_MOUSE] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.<ref>PMID:16373578</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Inducible arginine oxidation and subsequent NO production by correspondent synthase (iNOS) are important cellular answers to proinflammatory signals. Prolonged NO production has been proved in higher organisms to cause stroke or septic shock. Several classes of potent NOS inhibitors have been reported, most of them targeting the arginine binding site of the oxygenase domain. Here we disclose the SAR and the rational design of potent and selective iNOS inhibitors which may be useful as anti-inflammatory drugs.
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===Novel nanomolar Imidazopyridines as selective Nitric Oxide Synthase (iNOS) inhibitors: SAR and structural insights===
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Novel nanomolar imidazo[4,5-b]pyridines as selective nitric oxide synthase (iNOS) inhibitors: SAR and structural insights.,Gradler U, Fuchss T, Ulrich WR, Boer R, Strub A, Hesslinger C, Anezo C, Diederichs K, Zaliani A Bioorg Med Chem Lett. 2011 Jul 15;21(14):4228-32. Epub 2011 May 30. PMID:21684157<ref>PMID:21684157</ref>
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{{ABSTRACT_PUBMED_21684157}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 3nw2" style="background-color:#fffaf0;"></div>
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[[3nw2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NW2 OCA].
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==See Also==
==See Also==
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*[[Nitric Oxide Synthase|Nitric Oxide Synthase]]
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*[[Nitric Oxide Synthase 3D structures|Nitric Oxide Synthase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:021684157</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Nitric-oxide synthase]]
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[[Category: Anezo C]]
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[[Category: Anezo, C.]]
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[[Category: Boer R]]
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[[Category: Boer, R.]]
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[[Category: Diederichs K]]
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[[Category: Diederichs, K.]]
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[[Category: Fuchss T]]
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[[Category: Fuchss, T.]]
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[[Category: Graedler U]]
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[[Category: Graedler, U.]]
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[[Category: Hesslinger C]]
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[[Category: Hesslinger, C.]]
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[[Category: Strub A]]
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[[Category: Strub, A.]]
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[[Category: Ulrich WR]]
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[[Category: Ulrich, W R.]]
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[[Category: Zaliani A]]
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[[Category: Zaliani, A.]]
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[[Category: Calmodulin-binding]]
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[[Category: Fad]]
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[[Category: Fmn]]
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[[Category: Iron]]
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[[Category: Metal-binding]]
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[[Category: Nadp]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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Current revision

Novel nanomolar Imidazopyridines as selective Nitric Oxide Synthase (iNOS) inhibitors: SAR and structural insights

PDB ID 3nw2

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