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4ds0

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[[Image:4ds0.png|left|200px]]
 
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{{STRUCTURE_4ds0| PDB=4ds0 | SCENE= }}
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==Cell attachment protein VP8* of a human rotavirus specifically interacts with A-type histo-blood group antigen==
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<StructureSection load='4ds0' size='340' side='right'caption='[[4ds0]], [[Resolution|resolution]] 1.56&Aring;' scene=''>
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===Cell attachment protein VP8* of a human rotavirus specifically interacts with A-type histo-blood group antigen===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4ds0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rotavirus_sp. Rotavirus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DS0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DS0 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_22504179}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.56&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PRD_900132:Blood+group+A+H+type+2+antigen,+beta+anomer'>PRD_900132</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ds0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ds0 OCA], [https://pdbe.org/4ds0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ds0 RCSB], [https://www.ebi.ac.uk/pdbsum/4ds0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ds0 ProSAT]</span></td></tr>
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[[4ds0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rotavirus_sp. Rotavirus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DS0 OCA].
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</table>
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== Function ==
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==See Also==
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[https://www.uniprot.org/uniprot/Q86169_9REOV Q86169_9REOV] Outer capsid protein VP5*: forms the spike "foot" and "body". Acts as a membrane permeabilization protein that mediates release of viral particles from endosomal compartments into the cytoplasm. In integrin-dependent strains, VP5* targets the integrin heterodimer ITGA2/ITGB1 for cell attachment.[SAAS:SAAS00136874] VP8* forms the head of the spikes. It is the viral hemagglutinin and an important target of neutralizing antibodies. In sialic acid-dependent strains, VP8* binds to host cell sialic acid, most probably a ganglioside, providing the initial contact.[SAAS:SAAS00136880]
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*[[Virus coat protein|Virus coat protein]]
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__TOC__
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</StructureSection>
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==Reference==
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[[Category: Large Structures]]
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<ref group="xtra">PMID:022504179</ref><references group="xtra"/>
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[[Category: Rotavirus sp]]
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[[Category: Rotavirus sp.]]
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[[Category: Cortes-Penfield NW]]
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[[Category: Cortes-Penfield, N W.]]
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[[Category: Crawford SE]]
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[[Category: Crawford, S E.]]
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[[Category: Czako R]]
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[[Category: Czako, R.]]
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[[Category: Estes MK]]
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[[Category: Estes, M K.]]
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[[Category: Hu L]]
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[[Category: Hu, L.]]
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[[Category: Le Pendu J]]
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[[Category: Pendu, J Le.]]
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[[Category: Prasad BVV]]
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[[Category: Prasad, B V.V.]]
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[[Category: Smith DF]]
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[[Category: Smith, D F.]]
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[[Category: Cell attachment factor]]
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[[Category: Galectin-fold]]
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[[Category: Histo blood group antigen]]
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[[Category: Otavirus]]
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[[Category: Viral protein]]
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Current revision

Cell attachment protein VP8* of a human rotavirus specifically interacts with A-type histo-blood group antigen

PDB ID 4ds0

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