1q3e

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[[Image:1q3e.png|left|200px]]
 
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{{STRUCTURE_1q3e| PDB=1q3e | SCENE= }}
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==HCN2J 443-645 in the presence of cGMP==
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<StructureSection load='1q3e' size='340' side='right'caption='[[1q3e]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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===HCN2J 443-645 in the presence of cGMP===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1q3e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q3E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q3E FirstGlance]. <br>
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{{ABSTRACT_PUBMED_12968185}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PCG:CYCLIC+GUANOSINE+MONOPHOSPHATE'>PCG</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q3e OCA], [https://pdbe.org/1q3e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q3e RCSB], [https://www.ebi.ac.uk/pdbsum/1q3e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q3e ProSAT]</span></td></tr>
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[[1q3e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q3E OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HCN2_MOUSE HCN2_MOUSE] Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Produces a large instantaneous current. Activated by cAMP. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages.<ref>PMID:11741901</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q3/1q3e_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1q3e ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Ion channels|Ion channels]]
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*[[Ion channels 3D structures|Ion channels 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:012968185</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Black, K D.]]
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[[Category: Black KD]]
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[[Category: Gouaux, J E.]]
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[[Category: Gouaux JE]]
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[[Category: Olivier, N B.]]
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[[Category: Olivier NB]]
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[[Category: Olson, R.]]
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[[Category: Olson R]]
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[[Category: Young, E C.]]
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[[Category: Young EC]]
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[[Category: Zagotta, W N.]]
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[[Category: Zagotta WN]]
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[[Category: C-linker]]
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[[Category: Cap]]
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[[Category: Cgmp]]
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[[Category: Channel]]
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[[Category: Cnbd]]
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[[Category: Cyclic nucleotide]]
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[[Category: Hcn]]
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[[Category: Ion channel]]
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[[Category: Ligand]]
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[[Category: Pacemaker]]
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[[Category: Pka]]
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[[Category: Transport protein]]
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Current revision

HCN2J 443-645 in the presence of cGMP

PDB ID 1q3e

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