3qak

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:07, 9 October 2024) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3qak.png|left|200px]]
 
-
{{STRUCTURE_3qak| PDB=3qak | SCENE= }}
+
==Agonist bound structure of the human adenosine A2a receptor==
 +
<StructureSection load='3qak' size='340' side='right'caption='[[3qak]], [[Resolution|resolution]] 2.71&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[3qak]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QAK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QAK FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.71&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=UKA:6-(2,2-DIPHENYLETHYLAMINO)-9-[(2R,3R,4S,5S)-5-(ETHYLCARBAMOYL)-3,4-DIHYDROXY-OXOLAN-2-YL]-N-[2-[(1-PYRIDIN-2-YLPIPERIDIN-4-YL)CARBAMOYLAMINO]ETHYL]PURINE-2-CARBOXAMIDE'>UKA</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qak FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qak OCA], [https://pdbe.org/3qak PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qak RCSB], [https://www.ebi.ac.uk/pdbsum/3qak PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qak ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/AA2AR_HUMAN AA2AR_HUMAN] Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.[https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Activation of G protein-coupled receptors upon agonist binding is a critical step in the signaling cascade for this family of cell surface proteins. We report the crystal structure of the A(2A) adenosine receptor (A(2A)AR) bound to an agonist UK-432097 at 2.7 angstrom resolution. Relative to inactive, antagonist-bound A(2A)AR, the agonist-bound structure displays an outward tilt and rotation of the cytoplasmic half of helix VI, a movement of helix V, and an axial shift of helix III, resembling the changes associated with the active-state opsin structure. Additionally, a seesaw movement of helix VII and a shift of extracellular loop 3 are likely specific to A(2A)AR and its ligand. The results define the molecule UK-432097 as a "conformationally selective agonist" capable of receptor stabilization in a specific active-state configuration.
-
===Agonist bound structure of the human adenosine A2a receptor===
+
Structure of an agonist-bound human A2A adenosine receptor.,Xu F, Wu H, Katritch V, Han GW, Jacobson KA, Gao ZG, Cherezov V, Stevens RC Science. 2011 Apr 15;332(6027):322-7. Epub 2011 Mar 10. PMID:21393508<ref>PMID:21393508</ref>
-
{{ABSTRACT_PUBMED_21393508}}
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
 
+
</div>
-
==About this Structure==
+
<div class="pdbe-citations 3qak" style="background-color:#fffaf0;"></div>
-
[[3qak]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QAK OCA].
+
==See Also==
==See Also==
-
*[[G protein-coupled receptor|G protein-coupled receptor]]
+
*[[Adenosine A2A receptor 3D structures|Adenosine A2A receptor 3D structures]]
-
*[[Hen Egg-White (HEW) Lysozyme|Hen Egg-White (HEW) Lysozyme]]
+
*[[Lysozyme 3D structures|Lysozyme 3D structures]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<ref group="xtra">PMID:021393508</ref><references group="xtra"/>
+
__TOC__
-
[[Category: Enterobacteria phage t4]]
+
</StructureSection>
-
[[Category: Lysozyme]]
+
[[Category: Escherichia virus T4]]
-
[[Category: Cherezov, V.]]
+
[[Category: Homo sapiens]]
-
[[Category: GPCR, GPCR Network.]]
+
[[Category: Large Structures]]
-
[[Category: Han, G W.]]
+
[[Category: Cherezov V]]
-
[[Category: JCIMPT, Joint center for innovative membrane protein technologies.]]
+
[[Category: Han GW]]
-
[[Category: Katritch, V.]]
+
[[Category: Katritch V]]
-
[[Category: Stevens, R.]]
+
[[Category: Stevens R]]
-
[[Category: Wu, H.]]
+
[[Category: Wu H]]
-
[[Category: Xu, F.]]
+
[[Category: Xu F]]
-
[[Category: Gpcr]]
+
-
[[Category: Gpcr network]]
+
-
[[Category: Hydrolase]]
+
-
[[Category: Jcimpt]]
+
-
[[Category: Joint center for innovative membrane protein technology]]
+
-
[[Category: Membrane protein]]
+
-
[[Category: Protein structure initiative]]
+
-
[[Category: Psi-biology]]
+
-
[[Category: Receptor]]
+
-
[[Category: Signaling protein]]
+
-
[[Category: Structural genomic]]
+

Current revision

Agonist bound structure of the human adenosine A2a receptor

PDB ID 3qak

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3qak"
Personal tools