2qe5

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[[Image:2qe5.png|left|200px]]
 
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{{STRUCTURE_2qe5| PDB=2qe5 | SCENE= }}
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==Structure of HCV NS5B Bound to an Anthranilic Acid Inhibitor==
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<StructureSection load='2qe5' size='340' side='right'caption='[[2qe5]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2qe5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepatitis_C_virus_subtype_1b Hepatitis C virus subtype 1b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QE5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QE5 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=617:2-{[(4-CHLOROPHENOXY)ACETYL]AMINO}BENZOIC+ACID'>617</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qe5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qe5 OCA], [https://pdbe.org/2qe5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qe5 RCSB], [https://www.ebi.ac.uk/pdbsum/2qe5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qe5 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q99AU2_9HEPC Q99AU2_9HEPC]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qe/2qe5_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qe5 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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A series of potent anthranilic acid-based inhibitors of the hepatitis C NS5B polymerase has been identified. The inhibitors bind to a site on NS5B between the thumb and palm regions adjacent to the active site as determined by X-ray crystallography of the enzyme-inhibitor complex. Guided by both molecular modeling and traditional SAR, the enzyme activity of the initial hit was improved by approximately 100-fold, yielding a series of potent and selective NS5B inhibitors with IC50 values as low as 10 nM. These compounds were also inhibitors of the HCV replicon in cultured HUH7 cells.
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===Structure of HCV NS5B Bound to an Anthranilic Acid Inhibitor===
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Identification of anthranilic acid derivatives as a novel class of allosteric inhibitors of hepatitis C NS5B polymerase.,Nittoli T, Curran K, Insaf S, DiGrandi M, Orlowski M, Chopra R, Agarwal A, Howe AY, Prashad A, Floyd MB, Johnson B, Sutherland A, Wheless K, Feld B, O'Connell J, Mansour TS, Bloom J J Med Chem. 2007 May 3;50(9):2108-16. Epub 2007 Apr 3. PMID:17402724<ref>PMID:17402724</ref>
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{{ABSTRACT_PUBMED_17402724}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2qe5" style="background-color:#fffaf0;"></div>
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[[2qe5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus_subtype_1b Hepatitis c virus subtype 1b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QE5 OCA].
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==See Also==
==See Also==
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*[[RNA polymerase|RNA polymerase]]
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*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:017402724</ref><references group="xtra"/>
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__TOC__
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[[Category: Hepatitis c virus subtype 1b]]
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</StructureSection>
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[[Category: RNA-directed RNA polymerase]]
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[[Category: Hepatitis C virus subtype 1b]]
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[[Category: Bard, J.]]
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[[Category: Large Structures]]
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[[Category: Chopra, R.]]
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[[Category: Bard J]]
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[[Category: Svenson, K.]]
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[[Category: Chopra R]]
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[[Category: Transferase]]
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[[Category: Svenson K]]
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[[Category: Transferase polymerase]]
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Current revision

Structure of HCV NS5B Bound to an Anthranilic Acid Inhibitor

PDB ID 2qe5

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OCA

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