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3edx

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[[Image:3edx.png|left|200px]]
 
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{{STRUCTURE_3edx| PDB=3edx | SCENE= }}
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==Crystal structure of the W215A/E217A mutant of murine thrombin==
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<StructureSection load='3edx' size='340' side='right'caption='[[3edx]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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===Crystal structure of the W215A/E217A mutant of murine thrombin===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3edx]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EDX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EDX FirstGlance]. <br>
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{{ABSTRACT_PUBMED_15252033}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3edx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3edx OCA], [https://pdbe.org/3edx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3edx RCSB], [https://www.ebi.ac.uk/pdbsum/3edx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3edx ProSAT]</span></td></tr>
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[[3edx]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EDX OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/THRB_MOUSE THRB_MOUSE] Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ed/3edx_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3edx ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Thrombin|Thrombin]]
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*[[Thrombin 3D Structures|Thrombin 3D Structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:015252033</ref><ref group="xtra">PMID:019586901</ref><references group="xtra"/>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Thrombin]]
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[[Category: Bush-pelc L]]
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[[Category: Bush-pelc, L.]]
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[[Category: Chen Z]]
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[[Category: Cera, E Di.]]
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[[Category: Di Cera E]]
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[[Category: Chen, Z.]]
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[[Category: Gandhi PS]]
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[[Category: Gandhi, P S.]]
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[[Category: Page MJ]]
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[[Category: Page, M J.]]
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[[Category: Acute phase]]
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[[Category: Blood coagulation]]
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[[Category: Cleavage on pair of basic residue]]
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[[Category: Gamma-carboxyglutamic acid]]
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[[Category: Glycoprotein]]
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[[Category: Hydrolase]]
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[[Category: Kringle]]
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[[Category: Protease]]
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[[Category: Serine protease]]
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[[Category: Zymogen]]
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Current revision

Crystal structure of the W215A/E217A mutant of murine thrombin

PDB ID 3edx

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