2f92

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[[Image:2f92.png|left|200px]]
 
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{{STRUCTURE_2f92| PDB=2f92 | SCENE= }}
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==Crystal structure of human FPPS in complex with alendronate==
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<StructureSection load='2f92' size='340' side='right'caption='[[2f92]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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===Crystal structure of human FPPS in complex with alendronate===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2f92]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F92 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F92 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_16892359}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AHD:4-AMINO-1-HYDROXYBUTANE-1,1-DIYLDIPHOSPHONATE'>AHD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f92 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f92 OCA], [https://pdbe.org/2f92 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f92 RCSB], [https://www.ebi.ac.uk/pdbsum/2f92 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f92 ProSAT]</span></td></tr>
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[[2f92]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F92 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f9/2f92_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f92 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Farnesyl diphosphate synthase|Farnesyl diphosphate synthase]]
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*[[Farnesyl diphosphate synthase 3D structures|Farnesyl diphosphate synthase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:016892359</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bitsch, F.]]
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[[Category: Large Structures]]
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[[Category: Bourgier, E.]]
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[[Category: Bitsch F]]
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[[Category: Geiser, M.]]
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[[Category: Bourgier E]]
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[[Category: Green, J R.]]
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[[Category: Geiser M]]
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[[Category: Hemmig, R.]]
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[[Category: Green JR]]
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[[Category: Jahnke, W.]]
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[[Category: Hemmig R]]
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[[Category: Kroemer, M.]]
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[[Category: Jahnke W]]
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[[Category: Lehmann, S.]]
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[[Category: Kroemer M]]
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[[Category: Ramage, P.]]
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[[Category: Lehmann S]]
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[[Category: Rieffel, S.]]
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[[Category: Ramage P]]
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[[Category: Rondeau, J M.]]
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[[Category: Rieffel S]]
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[[Category: Strauss, A.]]
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[[Category: Rondeau J-M]]
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[[Category: Bisphosphonate inhibitor]]
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[[Category: Strauss A]]
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[[Category: Cholesterol biosynthesis]]
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[[Category: Isoprene biosynthesis]]
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[[Category: Mevalonate pathway]]
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[[Category: Transferase]]
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Current revision

Crystal structure of human FPPS in complex with alendronate

PDB ID 2f92

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