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3qyl
From Proteopedia
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| - | [[Image:3qyl.png|left|200px]] | ||
| - | + | ==Sensitivity of receptor internal motions to ligand binding affinity and kinetic off-rate== | |
| - | + | <StructureSection load='3qyl' size='340' side='right'caption='[[3qyl]], [[Resolution|resolution]] 1.79Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3qyl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QYL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QYL FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.79Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7ME:(7S)-7-METHYL-5,6,7,8-TETRAHYDROQUINAZOLINE-2,4-DIAMINE'>7ME</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qyl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qyl OCA], [https://pdbe.org/3qyl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qyl RCSB], [https://www.ebi.ac.uk/pdbsum/3qyl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qyl ProSAT]</span></td></tr> |
| - | [[3qyl]] is a 1 chain structure with sequence from [ | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DYR_ECOLI DYR_ECOLI] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | ||
==See Also== | ==See Also== | ||
| - | *[[Dihydrofolate reductase|Dihydrofolate reductase]] | + | *[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]] |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | [[Category: Escherichia coli K-12]] | |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Carroll MJ]] |
| - | [[Category: Carroll | + | [[Category: Collins EJ]] |
| - | [[Category: Collins | + | [[Category: Gromova AV]] |
| - | [[Category: Gromova | + | [[Category: Lee AL]] |
| - | [[Category: Lee | + | [[Category: Mauldin RV]] |
| - | [[Category: Mauldin | + | [[Category: Singleton SF]] |
| - | [[Category: Singleton | + | |
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Current revision
Sensitivity of receptor internal motions to ligand binding affinity and kinetic off-rate
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