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3qrf
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| - | [[Image:3qrf.png|left|200px]] | ||
| - | + | ==Structure of a domain-swapped FOXP3 dimer== | |
| - | + | <StructureSection load='3qrf' size='340' side='right'caption='[[3qrf]], [[Resolution|resolution]] 2.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3qrf]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QRF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QRF FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qrf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qrf OCA], [https://pdbe.org/3qrf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qrf RCSB], [https://www.ebi.ac.uk/pdbsum/3qrf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qrf ProSAT]</span></td></tr> |
| - | [[3qrf]] is a 10 chain structure with sequence from [ | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NFAC2_HUMAN NFAC2_HUMAN] Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF. Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway.<ref>PMID:21871017</ref> | ||
==See Also== | ==See Also== | ||
| - | *[[ | + | *[[FOX 3D structures|FOX 3D structures]] |
| - | + | == References == | |
| - | + | <references/> | |
| - | == | + | __TOC__ |
| - | < | + | </StructureSection> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Bandukwala | + | [[Category: Large Structures]] |
| - | [[Category: Barbosa | + | [[Category: Bandukwala HS]] |
| - | [[Category: Benoist | + | [[Category: Barbosa B]] |
| - | [[Category: Chen | + | [[Category: Benoist C]] |
| - | [[Category: Chen | + | [[Category: Chen L]] |
| - | [[Category: Feurer | + | [[Category: Chen Y]] |
| - | [[Category: Ghosh | + | [[Category: Feurer M]] |
| - | [[Category: Mathis | + | [[Category: Ghosh S]] |
| - | [[Category: Rao | + | [[Category: Mathis D]] |
| - | [[Category: Stroud | + | [[Category: Rao A]] |
| - | [[Category: Wu | + | [[Category: Stroud JC]] |
| - | + | [[Category: Wu Y]] | |
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Current revision
Structure of a domain-swapped FOXP3 dimer
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Categories: Homo sapiens | Large Structures | Bandukwala HS | Barbosa B | Benoist C | Chen L | Chen Y | Feurer M | Ghosh S | Mathis D | Rao A | Stroud JC | Wu Y
