3jsb

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[[Image:3jsb.png|left|200px]]
 
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{{STRUCTURE_3jsb| PDB=3jsb | SCENE= }}
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==Crystal structure of the N-terminal domain of the Lymphocytic Choriomeningitis Virus L protein==
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<StructureSection load='3jsb' size='340' side='right'caption='[[3jsb]], [[Resolution|resolution]] 2.13&Aring;' scene=''>
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===Crystal structure of the N-terminal domain of the Lymphocytic Choriomeningitis Virus L protein===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3jsb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lymphocytic_choriomeningitis_virus_(strain_Armstrong) Lymphocytic choriomeningitis virus (strain Armstrong)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JSB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JSB FirstGlance]. <br>
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{{ABSTRACT_PUBMED_20862324}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.13&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jsb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jsb OCA], [https://pdbe.org/3jsb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jsb RCSB], [https://www.ebi.ac.uk/pdbsum/3jsb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jsb ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[3jsb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lymphocytic_choriomeningitis_virus Lymphocytic choriomeningitis virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JSB OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/L_LYCVA L_LYCVA] RNA-dependent RNA polymerase which is responsible for replication and transcription of the viral RNA genome. During transcription, synthesizes 4 subgenomic RNAs, and assures their capping by a cap-snatching mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. The 3'-end of subgenomic mRNAs molecules are heterogeneous and not polyadenylated. The replicase function is to direct synthesis of antigenomic and genomic RNA which are encapsidated and non capped. As a consequence of the use of the same enzyme for both transcription and replication, these mechanisms need to be well coordinated. These processes may be regulated by proteins N and Z in a dose-dependent manner.<ref>PMID:7682625</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/js/3jsb_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3jsb ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[RNA polymerase|RNA polymerase]]
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*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:020862324</ref><references group="xtra"/>
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__TOC__
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[[Category: Lymphocytic choriomeningitis virus]]
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</StructureSection>
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[[Category: RNA-directed RNA polymerase]]
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[[Category: Large Structures]]
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[[Category: Bricogne, G.]]
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[[Category: Bricogne G]]
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[[Category: Canard, B.]]
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[[Category: Canard B]]
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[[Category: Coutard, B.]]
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[[Category: Coutard B]]
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[[Category: Ferron, F P.]]
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[[Category: Ferron FP]]
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[[Category: Jamal, S.]]
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[[Category: Jamal S]]
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[[Category: MSGP, Marseilles Structural Genomics Program.@.AFMB.]]
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[[Category: Morin B]]
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[[Category: Morin, B.]]
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[[Category: Vonrhein C]]
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[[Category: Vonrhein, C.]]
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[[Category: Marseilles structural genomics program @ afmb]]
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[[Category: Msgp]]
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[[Category: Nucleotide-binding]]
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[[Category: Nucleotidyltransferase]]
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[[Category: Rna binding protein]]
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[[Category: Rna replication]]
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[[Category: Rna-directed rna polymerase]]
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[[Category: Structural genomic]]
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[[Category: Transferase]]
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[[Category: Viral protein]]
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[[Category: Virion]]
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[[Category: Vizier]]
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Current revision

Crystal structure of the N-terminal domain of the Lymphocytic Choriomeningitis Virus L protein

PDB ID 3jsb

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