3f3f

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[[Image:3f3f.png|left|200px]]
 
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{{STRUCTURE_3f3f| PDB=3f3f | SCENE= }}
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==Crystal structure of the nucleoporin pair Nup85-Seh1, space group P21==
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<StructureSection load='3f3f' size='340' side='right'caption='[[3f3f]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3f3f]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F3F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F3F FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f3f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f3f OCA], [https://pdbe.org/3f3f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f3f RCSB], [https://www.ebi.ac.uk/pdbsum/3f3f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f3f ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NUP85_YEAST NUP85_YEAST] Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. NUP85 is involved in nuclear poly(A)+ RNA and pre-ribosome export, in GSP1 nuclear import, in NPC assembly and distribution, as well as in nuclear envelope organization.<ref>PMID:8816998</ref> <ref>PMID:9774696</ref> <ref>PMID:11071906</ref> <ref>PMID:12543930</ref> <ref>PMID:11823431</ref> <ref>PMID:12730220</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f3/3f3f_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3f3f ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We recently proposed a cylindrical coat for the nuclear pore membrane in the nuclear pore complex (NPC). This scaffold is generated by multiple copies of seven nucleoporins. Here, we report three crystal structures of the nucleoporin pair Seh1*Nup85, which is part of the coat cylinder. The Seh1*Nup85 assembly bears resemblance in its shape and dimensions to that of another nucleoporin pair, Sec13*Nup145C. Furthermore, the Seh1*Nup85 structures reveal a hinge motion that may facilitate conformational changes in the NPC during import of integral membrane proteins and/or during nucleocytoplasmic transport. We propose that Seh1*Nup85 and Sec13*Nup145C form 16 alternating, vertical rods that are horizontally linked by the three remaining nucleoporins of the coat cylinder. Shared architectural and mechanistic principles with the COPII coat indicate a common evolutionary origin and support the notion that the NPC coat represents another class of membrane coats.
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===Crystal structure of the nucleoporin pair Nup85-Seh1, space group P21===
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A fence-like coat for the nuclear pore membrane.,Debler EW, Ma Y, Seo HS, Hsia KC, Noriega TR, Blobel G, Hoelz A Mol Cell. 2008 Dec 26;32(6):815-26. PMID:19111661<ref>PMID:19111661</ref>
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{{ABSTRACT_PUBMED_19111661}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 3f3f" style="background-color:#fffaf0;"></div>
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[[3f3f]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F3F OCA].
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==See Also==
==See Also==
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*[[Beta secretase|Beta secretase]]
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*[[Nucleoporin 3D structures|Nucleoporin 3D structures]]
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*[[Nucleoporin|Nucleoporin]]
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:019111661</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Blobel, G.]]
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[[Category: Blobel G]]
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[[Category: Debler, E W.]]
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[[Category: Debler EW]]
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[[Category: Hoelz, A.]]
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[[Category: Hoelz A]]
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[[Category: Hseo, H.]]
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[[Category: Hseo H]]
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[[Category: Ma, Y.]]
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[[Category: Ma Y]]
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[[Category: Beta-propeller]]
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[[Category: Macromolecular assembly]]
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[[Category: Membrane coat]]
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[[Category: Mrna transport]]
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[[Category: Nuclear pore complex]]
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[[Category: Nucleocytoplasmic transport]]
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[[Category: Nucleoporin]]
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[[Category: Nucleoporin complex]]
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[[Category: Nucleus]]
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[[Category: Protein complex]]
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[[Category: Protein transport]]
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[[Category: Solenoid domain]]
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[[Category: Structural protein]]
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[[Category: Translocation]]
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[[Category: Wd repeat]]
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Current revision

Crystal structure of the nucleoporin pair Nup85-Seh1, space group P21

PDB ID 3f3f

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