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1jyq

From Proteopedia

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[[Image:1jyq.png|left|200px]]
 
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{{STRUCTURE_1jyq| PDB=1jyq | SCENE= }}
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==Xray Structure of Grb2 SH2 Domain Complexed with a Highly Affine Phospho Peptide==
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<StructureSection load='1jyq' size='340' side='right'caption='[[1jyq]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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===Xray Structure of Grb2 SH2 Domain Complexed with a Highly Affine Phospho Peptide===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1jyq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JYQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JYQ FirstGlance]. <br>
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{{ABSTRACT_PUBMED_11827484}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MAZ:FORMIC+ACID+3-AMINO-BENZYL+ESTER'>MAZ</scene>, <scene name='pdbligand=PTM:ALPHA-METHYL-O-PHOSPHOTYROSINE'>PTM</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jyq OCA], [https://pdbe.org/1jyq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jyq RCSB], [https://www.ebi.ac.uk/pdbsum/1jyq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jyq ProSAT]</span></td></tr>
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[[1jyq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JYQ OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GRB2_HUMAN GRB2_HUMAN] Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.<ref>PMID:1322798</ref> <ref>PMID:8178156</ref> <ref>PMID:19815557</ref> Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.<ref>PMID:1322798</ref> <ref>PMID:8178156</ref> <ref>PMID:19815557</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jy/1jyq_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jyq ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Growth factor receptor-bound protein 2|Growth factor receptor-bound protein 2]]
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*[[Growth factor receptor-bound proteins 3D structures|Growth factor receptor-bound proteins 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:011827484</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Broutin, I.]]
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[[Category: Large Structures]]
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[[Category: Charbonnier, F.]]
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[[Category: Broutin I]]
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[[Category: Ducruix, A.]]
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[[Category: Charbonnier F]]
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[[Category: Garbay, C.]]
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[[Category: Ducruix A]]
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[[Category: Latreille, M T.]]
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[[Category: Garbay C]]
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[[Category: Liu, W Q.]]
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[[Category: Latreille M-T]]
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[[Category: Nioche, P.]]
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[[Category: Liu W-Q]]
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[[Category: Roques, B.]]
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[[Category: Nioche P]]
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[[Category: Vidal, M.]]
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[[Category: Roques B]]
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[[Category: Receptor binding]]
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[[Category: Vidal M]]
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[[Category: Regulatory]]
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[[Category: Signaling protein-peptide inhibitor complex]]
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[[Category: Signaling protein-signaling protein inhibitor]]
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Current revision

Xray Structure of Grb2 SH2 Domain Complexed with a Highly Affine Phospho Peptide

PDB ID 1jyq

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