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1s2y

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[[Image:1s2y.png|left|200px]]
 
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{{STRUCTURE_1s2y| PDB=1s2y | SCENE= }}
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==Crystal structure of MAOB in complex with N-propargyl-1(S)-aminoindan==
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<StructureSection load='1s2y' size='340' side='right'caption='[[1s2y]], [[Resolution|resolution]] 2.12&Aring;' scene=''>
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===Crystal structure of MAOB in complex with N-propargyl-1(S)-aminoindan===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1s2y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S2Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S2Y FirstGlance]. <br>
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{{ABSTRACT_PUBMED_15027868}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.12&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=RSA:N-PROPARGYL-1(S)-AMINOINDAN'>RSA</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s2y OCA], [https://pdbe.org/1s2y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s2y RCSB], [https://www.ebi.ac.uk/pdbsum/1s2y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s2y ProSAT]</span></td></tr>
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[[1s2y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S2Y OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AOFB_HUMAN AOFB_HUMAN] Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/s2/1s2y_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1s2y ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
*[[Monoamine oxidase|Monoamine oxidase]]
*[[Monoamine oxidase|Monoamine oxidase]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:015027868</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Monoamine oxidase]]
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[[Category: Large Structures]]
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[[Category: Binda, C.]]
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[[Category: Binda C]]
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[[Category: Edmondson, D E.]]
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[[Category: Edmondson DE]]
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[[Category: Herzig, Y.]]
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[[Category: Herzig Y]]
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[[Category: Hubalek, F.]]
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[[Category: Hubalek F]]
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[[Category: Li, M.]]
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[[Category: Li M]]
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[[Category: Mattevi, A.]]
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[[Category: Mattevi A]]
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[[Category: Sterling, J.]]
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[[Category: Sterling J]]
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[[Category: Enantioselectivity]]
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[[Category: Flavin]]
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[[Category: Human monoamine oxidase]]
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[[Category: Inhibitor binding]]
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[[Category: Oxidoreductase]]
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[[Category: Rasagiline]]
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Current revision

Crystal structure of MAOB in complex with N-propargyl-1(S)-aminoindan

PDB ID 1s2y

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