2f4e

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:42, 23 August 2023) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2f4e.png|left|200px]]
 
-
{{STRUCTURE_2f4e| PDB=2f4e | SCENE= }}
+
==N-terminal domain of FKBP42 from Arabidopsis thaliana==
 +
<StructureSection load='2f4e' size='340' side='right'caption='[[2f4e]], [[Resolution|resolution]] 2.32&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[2f4e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F4E FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.32&#8491;</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f4e OCA], [https://pdbe.org/2f4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f4e RCSB], [https://www.ebi.ac.uk/pdbsum/2f4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f4e ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/FKB42_ARATH FKB42_ARATH] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Modulates the uptake of MRP substrates into the vacuole; reduces metolachlor-GS (MOC-GS) and enhances 17-beta-estradiol 17-(beta-D-glucuronide) (E(2)17betaG) uptake. Regulates cell elongation and orientation. Functions as a positive regulator of PGP1-mediated auxin transport. Confers drug modulation of PGP1 efflux activity as interaction with NPA or flavonol quercetin prevents its physical and functional interaction with PGP1. Required for the proper localization of auxin-related ABCB transporters. Plays a role in brassinosteroid (BR) signaling pathway.<ref>PMID:14517332</ref> <ref>PMID:15133126</ref> <ref>PMID:14730066</ref> <ref>PMID:16887800</ref> <ref>PMID:18499676</ref> <ref>PMID:20971896</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f4/2f4e_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f4e ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
We present the three-dimensional structure of the N-terminal FK506-binding protein (FKBP)-like domain of the immunophilin FKBP42 from Arabidopsis thaliana. The data provide the structural background for the explanation of key functional properties reported previously.
-
===N-terminal domain of FKBP42 from Arabidopsis thaliana===
+
Crystal structure of a plant immunophilin domain involved in regulation of MDR-type ABC transporters.,Weiergraber OH, Eckhoff A, Granzin J FEBS Lett. 2006 Jan 9;580(1):251-5. Epub 2005 Dec 12. PMID:16364310<ref>PMID:16364310</ref>
-
{{ABSTRACT_PUBMED_16364310}}
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
 
+
</div>
-
==About this Structure==
+
<div class="pdbe-citations 2f4e" style="background-color:#fffaf0;"></div>
-
[[2f4e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F4E OCA].
+
==See Also==
==See Also==
-
*[[Cyclophilin|Cyclophilin]]
+
*[[FKBP 3D structures|FKBP 3D structures]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<ref group="xtra">PMID:016364310</ref><references group="xtra"/>
+
__TOC__
 +
</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Arabidopsis thaliana]]
-
[[Category: Eckhoff, A.]]
+
[[Category: Large Structures]]
-
[[Category: Granzin, J.]]
+
[[Category: Eckhoff A]]
-
[[Category: Weiergraber, O H.]]
+
[[Category: Granzin J]]
-
[[Category: Alpha-beta]]
+
[[Category: Weiergraber OH]]
-
[[Category: Fkbp-like]]
+
-
[[Category: Signaling protein]]
+

Current revision

N-terminal domain of FKBP42 from Arabidopsis thaliana

PDB ID 2f4e

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2f4e"
Personal tools