1cza

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[[Image:1cza.png|left|200px]]
 
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{{STRUCTURE_1cza| PDB=1cza | SCENE= }}
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==MUTANT MONOMER OF RECOMBINANT HUMAN HEXOKINASE TYPE I COMPLEXED WITH GLUCOSE, GLUCOSE-6-PHOSPHATE, AND ADP==
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<StructureSection load='1cza' size='340' side='right'caption='[[1cza]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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===MUTANT MONOMER OF RECOMBINANT HUMAN HEXOKINASE TYPE I COMPLEXED WITH GLUCOSE, GLUCOSE-6-PHOSPHATE, AND ADP===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1cza]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CZA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CZA FirstGlance]. <br>
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{{ABSTRACT_PUBMED_10686099}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=G6P:ALPHA-D-GLUCOSE-6-PHOSPHATE'>G6P</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cza OCA], [https://pdbe.org/1cza PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cza RCSB], [https://www.ebi.ac.uk/pdbsum/1cza PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cza ProSAT]</span></td></tr>
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[[1cza]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CZA OCA].
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/HXK1_HUMAN HXK1_HUMAN] Defects in HK1 are the cause of hexokinase deficiency (HK deficiency) [MIM:[https://omim.org/entry/235700 235700]. HK deficiency is a rare autosomal recessive disease with nonspherocytic hemolytic anemia as the predominant clinical feature.
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== Function ==
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[https://www.uniprot.org/uniprot/HXK1_HUMAN HXK1_HUMAN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cz/1cza_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cza ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Hexokinase|Hexokinase]]
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*[[Hexokinase 3D structures|Hexokinase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:010686099</ref><references group="xtra"/>
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[[Category: Hexokinase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Aleshin, A E.]]
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[[Category: Large Structures]]
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[[Category: Bartunik, H D.]]
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[[Category: Aleshin AE]]
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[[Category: Bourenkov, G P.]]
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[[Category: Bartunik HD]]
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[[Category: Fromm, H J.]]
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[[Category: Bourenkov GP]]
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[[Category: Honzatko, R B.]]
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[[Category: Fromm HJ]]
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[[Category: Kirby, C.]]
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[[Category: Honzatko RB]]
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[[Category: Liu, X.]]
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[[Category: Kirby C]]
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[[Category: Structurally homologous domain]]
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[[Category: Liu X]]
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[[Category: Transferase]]
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Current revision

MUTANT MONOMER OF RECOMBINANT HUMAN HEXOKINASE TYPE I COMPLEXED WITH GLUCOSE, GLUCOSE-6-PHOSPHATE, AND ADP

PDB ID 1cza

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