3qjm

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[[Image:3qjm.png|left|200px]]
 
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{{STRUCTURE_3qjm| PDB=3qjm | SCENE= }}
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==Structural flexibility of Shank PDZ domain is important for its binding to different ligands==
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<StructureSection load='3qjm' size='340' side='right'caption='[[3qjm]], [[Resolution|resolution]] 2.31&Aring;' scene=''>
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===Structural flexibility of Shank PDZ domain is important for its binding to different ligands===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3qjm]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QJM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QJM FirstGlance]. <br>
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{{ABSTRACT_PUBMED_21376703}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.311&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qjm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qjm OCA], [https://pdbe.org/3qjm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qjm RCSB], [https://www.ebi.ac.uk/pdbsum/3qjm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qjm ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[3qjm]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QJM OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/SHAN1_RAT SHAN1_RAT] Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. Overexpression promotes maturation of dendritic spines and the enlargement of spine heads via its ability to recruit Homer to postsynaptic sites, and enhances presynaptic function.<ref>PMID:11498055</ref> <ref>PMID:18287537</ref>
==See Also==
==See Also==
*[[Shank protein|Shank protein]]
*[[Shank protein|Shank protein]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:021376703</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Eom, S H.]]
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[[Category: Eom SH]]
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[[Category: Kim, H J.]]
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[[Category: Kim HJ]]
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[[Category: Lee, J H.]]
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[[Category: Lee JH]]
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[[Category: Park, H.]]
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[[Category: Park H]]
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[[Category: Park, S J.]]
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[[Category: Park SJ]]
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[[Category: Beta-pix]]
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[[Category: Pdz domain]]
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[[Category: Protein binding]]
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[[Category: Protein-protein interaction]]
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Current revision

Structural flexibility of Shank PDZ domain is important for its binding to different ligands

PDB ID 3qjm

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