3na0

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:28, 21 February 2024) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3na0.png|left|200px]]
 
-
{{STRUCTURE_3na0| PDB=3na0 | SCENE= }}
+
==Crystal structure of human CYP11A1 in complex with 20,22-dihydroxycholesterol==
-
 
+
<StructureSection load='3na0' size='340' side='right'caption='[[3na0]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-
===Crystal structure of human CYP11A1 in complex with 20,22-dihydroxycholesterol===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[3na0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NA0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NA0 FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_21636783}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2DC:(3ALPHA,8ALPHA,22R)-CHOLEST-5-ENE-3,20,22-TRIOL'>2DC</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3na0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3na0 OCA], [https://pdbe.org/3na0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3na0 RCSB], [https://www.ebi.ac.uk/pdbsum/3na0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3na0 ProSAT]</span></td></tr>
-
[[3na0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NA0 OCA].
+
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/CP11A_HUMAN CP11A_HUMAN] Inherited isolated adrenal insufficiency due to CYP11A1 deficiency;46,XY disorder of sex development - adrenal insufficiency due to CYP11A1 deficiency. The disease is caused by mutations affecting the gene represented in this entry.
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/CP11A_HUMAN CP11A_HUMAN] Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone.<ref>PMID:21636783</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/na/3na0_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3na0 ConSurf].
 +
<div style="clear:both"></div>
==See Also==
==See Also==
-
*[[Ferredoxin|Ferredoxin]]
+
*[[Ferredoxin 3D structures|Ferredoxin 3D structures]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<ref group="xtra">PMID:021636783</ref><references group="xtra"/>
+
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Arrowsmith, C H.]]
+
[[Category: Large Structures]]
-
[[Category: Botchkarev, A.]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Bountra, C.]]
+
[[Category: Botchkarev A]]
-
[[Category: Edwards, A M.]]
+
[[Category: Bountra C]]
-
[[Category: MacKenzie, F.]]
+
[[Category: Edwards AM]]
-
[[Category: Park, H.]]
+
[[Category: MacKenzie F]]
-
[[Category: SGC, Structural Genomics Consortium.]]
+
[[Category: Park H]]
-
[[Category: Strushkevich, N V.]]
+
[[Category: Strushkevich NV]]
-
[[Category: Tempel, W.]]
+
[[Category: Tempel W]]
-
[[Category: Weigelt, J U.]]
+
[[Category: Weigelt JU]]
-
[[Category: 20]]
+
-
[[Category: 22-dihydroxycholesterol]]
+
-
[[Category: Cytochrome p450]]
+
-
[[Category: Electron transport]]
+
-
[[Category: Oxidoreductase]]
+
-
[[Category: Sgc]]
+
-
[[Category: Side chain cleavage]]
+
-
[[Category: Structural genomic]]
+
-
[[Category: Structural genomics consortium]]
+

Current revision

Crystal structure of human CYP11A1 in complex with 20,22-dihydroxycholesterol

PDB ID 3na0

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3na0"
Personal tools